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diagnosis dermatology antimda5 antimda5dm antinxp2 antinxp2dm differential management myopathy myositis pathophysiology polymyositis symptoms vasculitis
Dermatomyositis (DM) and Polymyositis (PM): Pathogenesis and clinical findings Elevated Antinuclear Antibodies: Anti-Jo-1, Anti-OJ, Anti-Mi2, Anti-SRP, Anti-EJ,
Dermatomyositis ... and clinical findings ... processes occur in the skin ... -> Heliotrope Rash ... Pathophysiology #Signs
ANTI-MDA5 DERMATOMYOSITIS Cutaneous manifestations: • Periorbital heliotrope (blue-purple) rash with edema • Erythematous rash on the face, or the
chest (in a V-sign ... shoulders (in a shawl sign ... Inverse Gottron’s sign ... auricular papules Clinical ... #rheumatology #
Anti-NXP-2 Dermatomyositis What? DM with generalized subcutaneous edema Pts have more myalgias, more severe weakness, and an increased prevalence
DM with generalized ... chest (in a V-sign ... shoulders (in a shawl sign ... auricular papules Clinical ... diagnosis #management #rheumatology
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
) • Anti-Mi2 (skin ... papules and Gottron sign ... ) • Shawl sign ... are elevated < PM ... and DM • CPK 10X
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