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diagnosis hematology management blood dermatomyositis differential peds product reactions antimda5 antimda5dm antinxp2 antinxp2dm autoimmune common disorders distribution history myopathy myositis
ANTI-MDA5 DERMATOMYOSITIS Cutaneous manifestations: • Periorbital heliotrope (blue-purple) rash with edema • Erythematous rash on the face, or the
(blue-purple) rash ... • Erythematous rash ... severity of the disease ... Dermatomyositis #rheumatology ... #dermatology #diagnosis
Pediatrics Sepsis Screening SIGNS OF INFECTION? • Fever (>38C) • Hypothermia (<36C) • Cough/chest pain/respiratory distress •
Pediatrics Sepsis ... pain/swelling/rash ... • ↓ feeding, ... neuromuscular disease ... <94%, mottled skin
Helpful Clinical Features in Evaluating Bleeding Disorders Age of onset • Neonate - in 20% of haemophilias,
von Willebrand disease ... and skin haemorrhage ... History #peds #pediatrics ... #diagnosis #hematology ... #primarycare
Common Dermatological Conditions - Distribution and Morphology • Acne vulgaris - Face, upper back, chest -
associated with signs ... macerated areas with satellite ... ; pruritis #dermatology ... #rash #differential ... #distribution #primarycare
Blood Transfusion Reactions Immune Mediated: • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
maculopapular rash ... Graft Versus Host Disease ... infections with skin ... Borrellia (Lyme disease ... diagnosis #management #hematology
Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
maculopapular rash ... coagulopathy & ↑bleeding ... infections with skin ... Borrellia (Lyme disease ... diagnosis #management #hematology
Anti-NXP-2 Dermatomyositis What? DM with generalized subcutaneous edema Pts have more myalgias, more severe weakness, and an increased prevalence
(blue-purple) rash ... • Erythematous rash ... had more severe disease ... diagnosis #management #rheumatology ... #dermatology
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
RP-ILD), dermato-rheumatologic ... ) • Anti-Mi2 (skin ... Symptoms: • Gottron rash ... papules and Gottron sign ... ) • Shawl sign
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