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Systemic Sclerosis (Scleroderma)
Multi-system autoimmune disease characterized by vasculopathy and progressive fibrosis of skin and internal organs
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thickening Signs ... and Symptoms: ... : PBC (primary biliary ... cholangitis) overlap ... #symptoms #testing
Primary Biliary Cirrhosis (PBC) - Summary

PBC Epidemiology:
 • Female:Male 9:1
 • Common European descent
 • Age:
intralobular bile ducts causes ... failure PBC Signs ... and Symptoms: ... Examination: • Skin ... bile ducts Differential
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
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Vasculitides - Differential ... tract, and often causes ... Presentation - Systemic Symptoms ... , particularly scleritis ... purpura: strong sign
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
Presentation: Systemic Symptoms ... , particularly scleritis ... purpura: Strong sign ... • Progressive symptoms ... tract, and often causes