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diagnosis hematology algorithm causes systemic generalized pruritus agglutinin globulin hemolytic mds monoclonal myelodysplasia myelodysplastic naildisorders nonpalpable palpable paraproteinemias primary protein
Nail Disorders secondary to Systemic Diseases Nail Fold Abnormality • SLE • Scleroderma • Dermatomyositis Koilonychia - Spoon-shaped
Nail Disorders secondary ... Nail Fold Abnormality ... Iron deficiency anemia ... • Nephrotic syndrome ... #dermatology #Differential
Pruritus - Generalized Differential Diagnosis Algorithm - Systemic and Primary Causes == Primary Skin Lesions == Macules /
renal failure/uremia ... • Lymphoma • Leukemia ... Myelodisplastic syndrome ... Pruritus #primary #secondary ... #generalized #dermatology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
AIHA Primary Secondary ... lymphoproliferative disorder Secondary ... Syndrome (CAS): ... younger pts) Differential ... #hematology #diagnosis
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
extramedullary disease ... activity • ↓ LAP ... - infiltrates (anemia ... bone marrow and secondary ... #Hematology #Oncology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... leakage of RBC's secondary ... - Hemolytic anemia ... vasculitis - GPA ... #nonpalpable #dermatology
Pruritus - No Primary Skin Lesion - Differential Diagnosis Algorithm Blood Glucose: • Diabetes Mellitus Liver Function Tests/Enzymes:
renal failure/uremia ... • Lymphoma • Leukemia ... Myelodisplastic syndrome ... #Pruritus #secondary ... #generalized #dermatology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
(-) hemolytic anemia ... due to cold IgG ... Pseudohyponatremia • ↓anion gap ... #Monoclonal #Differential ... #Diagnosis #Oncology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
DDX: Rule Out Secondary ... • Hairy Cell Leukemia ... Myeloproliferative Disease ... blood count with differential ... #oncology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
• Plasma cell leukemia ... changes (POEMS syndrome ... : Lymphoma, Leukemia ... Thalassemia, Sickle cell anemia ... #ProteinGap #differential
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