1815 results
ILD of Known Cause - Differential Diagnosis
Exposure:
 • Occupational: Asbestosis, Silicosis, Hypersensitivity, Pneumonitis
 • Treatment Related:
ILD of Known Cause ... Tissue Disease: RA, Scleroderma ... BrighamChiefs #ILD
Systemic Sclerosis (Scleroderma)
Multi-system autoimmune disease characterized by vasculopathy and progressive fibrosis of skin and internal organs
3
Systemic Sclerosis (Scleroderma ... 3 Subtypes of Scleroderma ... Sclerosis sine scleroderma ... • Pulmonary: ILD ... HTN) • Renal: scleroderma
Systemic Sclerosis (Scleroderma)
Limited - CREST:
 • Calcinosis
 • Raynaud phenomenon
 • Esophageal dysmotility
 • Sclerodactyly
 •
Systemic Sclerosis (Scleroderma ... 10% - 15% • Scleroderma ... Systemic #Sclerosis #Scleroderma
ANA Patterns and Associated Rheumatic Diseases:
 • Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease
Systemic sclerosis or scleroderma ... systemic sclerosis/scleroderma ... systemic sclerosis/scleroderma ... Systemic sclerosis/scleroderma
Interstitial Lung Diseases (ILD)
Exposure-Related ILD (a.k.a. extrinsic allergic alveolitis): 
 • Hypersensitivity pneumonitis, Farmer's lung, Bird
Lung Diseases (ILD ... Exposure-Related ILD ... ILD caused by inhalation ... Medication-induced ILD ... Methotrexate ILD
Classification of COVID-19 Disease States and Potential Therapeutic Targets

Viral Response Phase -> Host Inflammatory Response Phase
Stage
Phase) Stage Ill ... immunoglobulin, IL ... -6 inhibitors, IL ... Classification #Diagnosis #Pathophysiology
Chronic Diarrhea Differential Diagnosis
 • Inflammatory, Infectious: Recurrent C. diff, Giardiasis
 • Inflammatory, Non-infectious: IBD, Ischemia,
Non-infectious: IBD ... Thyrotoxicosis, Scleroderma
Skin Conditions Associated with Joint Pain

Rash
	• Human parvovirus B19 infection

Malar rash
	• SLE
	• Human parvovirus B19 infection
	•
Telangiectasia • Scleroderma ... Thickened skin • Scleroderma ... gangrenosum • IBD
Aortic Regurgitation - Pathophysiology
 • Early Mild Aortic Regurgitation
 • Chronic Severe Aortic Regurgitation
 • Decompensated
Regurgitation - Pathophysiology ... • Early Mild ... Regurgitation #Pathophysiology
Heme Synthesis Pathway
Enzymes
1. ALA Synthase
2. ALA Dehydratase
3. Porphobilinogen deaminase
4. UP Ill Synthase
5. UP Ill Decarboxylase
6. Coproporphyrinogen
UP Ill Synthase ... UP Ill Decarboxylase ... Synthesis #Pathway #pathophysiology