18 results
Hypereosinophilia Syndrome (HES) - Diagnosis and Management
Definition: An absolute eosinophil count (AEC) greater than 1500 and
Definition: An absolute eosinophil ... attributable to eosinophilia ... confirmed tissue eosinophilia ... with blood eosinophilia ... #eosinophils
Biologic therapy for eosinophilic asthma 
• Mepolizumab (Nucala) 
  • Anti-lL-5, 100 mg SQ q4
Biologic therapy for eosinophilic ... • Peripheral eosinophils ... • Peripheral eosinophils ... #pharmacology #pulmonary ... #management
Hypereosinophilia and Hypereosinophilic Syndrome

 • Secondary Hypereosinophilic Syndrome
 • Clinically Relevant HES Variants
 • When to
Syndrome #HES #Hematology ... #eosinophilia # ... eosinophils #diagnosis ... #management #algorithm
Amiodarone-Induced Lung Iniurv (AILI) - Timeline
Hours to days (peri-procedurally): ARDS
Days to months: DAH
Weeks: Eosinophilic pneumonia
Weeks to
Amiodarone-Induced ... months: DAH Weeks: Eosinophilic ... BrighamChiefs #Amiodarone ... AILI #Timeline #pulmonary
Interstitial Lung Diseases (ILD)
Exposure-Related ILD (a.k.a. extrinsic allergic alveolitis): 
 • Hypersensitivity pneumonitis, Farmer's lung, Bird
Medication-induced ILD: Amiodarone ... • Idiopathic pulmonary ... polyangiitis, Eosinophilic ... syndrome) • Eosinophilic ... #differential #pulmonary
Amiodarone Induced Lung Toxicity Summary

Who?
• 5% of patients
• Dose ≥ 400 mg per day

How?  Possible
rarely present with eosinophilic ... pneumonia - Pulmonary ... pulmonary toxicity ... Neutrophilia • Eosinophilia ... #diagnosis #management
Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS)
Definition: 
 • Severe adverse drug reaction, characterized by
Reaction with Eosinophilia ... lymphadenopathy, eosinophilia ... Eosinophilia 4 ... DRESS #Syndrome #dermatology ... #diagnosis #management
Eosinophilic Gastroenteritis: Treatment Options Based on Severity of the Disease
Mild:
 • Trial of PPI
 • Trial
Eosinophilic Gastroenteritis ... Concern for HES: • Hematology ... scan #EoE #Eosinophilic ... Gastroenteritis #Treatment #management
Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Syndrome Treatment
Stop offending agents:
 • List as allergies
Reaction with Eosinophilia ... Syndrome #Treatment #Management ... #dermatology
Causes of Interstitial Lung Disease - Differential Diagnosis Algorithm
Idiopathic Interstitial Pneumonia
 • (UIP) Usual Interstitial Pneumonia
Lymphangioleiomyomatosis (LAM), • Pulmonary ... histiocytosis (PLCH) • Eosinophilic ... leaking out of pulmonary ... Radiaition • Drugs: Amiodarone