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diagnosis betadglucan galactomannan laboratory acth adrenal aspergillus biomarkers clinicopathology comparison endocrinology falsepositives hypercalcemia infections infectiousdiseases insufficiency management mycoses smallpox stimulation
Fungal Biomarkers: Beta-D-Glucan and Aspergillus Galactomannan Beta-D-Glucan: • Polysaccharide cell wall component of many fungi • Pathogens:
& Specificity: ... membranes synthetic now ... & Specificity ... BAL GM does not differentiate ... Frozen ice-pops (in setting
Diagnostic algorithm for the workup of hypercalcemia. The diagnostic workup for patients presenting with hypercalcemia rests
value of 0.0115, sensitivity ... for correct classification ... ) was 0.80 and specificity ... Thus, further testing ... Hypercalcemia #Workup #Differential
1,3-Beta-D-Glucan and Galactomannan Testing Sensitivity Specificity and False Positives 1,3-Beta-D-Glucan • Cell wall component of many fungi
Galactomannan Testing ... Sensitivity Specificity ... 96% • Higher specificity ... clinical situations, low ... in BAL does not differentiate
Diagnosis Adrenal Insufficiency - Algorithm Step 1) Screening Test: 6-8AM Cortisol Level - Early morning cortisol levels
have almost 100% specificity ... for AI (but low ... sensitivity) ... require Cosyntropin testing ... Step 3) Differentiate
Mycoses HISTOPLASMOSIS • Inhalation of conidia → Yeast → travel to lymph nodes → spread in body • Bird
antigen assay has a sensitivity ... and specificity ... Urinary antigen testing ... protein level • A low ... fever • Septic shock
6/02/2022 UPDATE: This assay is designed to detect non-variola orthopoxviruses, including monkeypox virus. It is not
monkeypox virus or to differentiate ... should use this algorithm ... risk of smallpox –low ... specimens from low ... See table below
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