ShamControlled pathophysiology complications hematology differential purpura syndrome dermatology secondary hemolytic disease skin diffuse diagnosis agglutinin anemia pruritus

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Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
• Mechanical Trauma (Microangiopathic hemolytic anemia):

Diagnostic Framework ... thrombocytopenic purpura ... . primary cold agglutin ... Extravascular #Causes #differential ... #diagnosis #hematology

Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
1. Cold Agglutinins (CAD)
2. Donath-Landsteiner

Syndrome (CAS): ... Diagnosis: • hemolytic ... younger pts) Differential ... #disease #hemolytic ... #anemia #hematology

Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage

Purpura - Differential ... purple, hemorrhagic skin ... anemia - Splenomegaly ... Diagnosis #hematology ... #nonpalpable #dermatology

Pruritus - Generalized Differential Diagnosis Algorithm - Systemic and Primary Causes
== Primary Skin Lesions ==
Macules /

Pruritus - Generalized ... Differential Diagnosis ... Myelodisplastic syndrome ... #primary #secondary ... #generalized #dermatology

Pruritus - No Primary Skin Lesion - Differential Diagnosis Algorithm

Blood Glucose:
• Diabetes Mellitus
Liver Function Tests/Enzymes:

Skin Lesion - Differential ... renal failure/uremia ... Myelodisplastic syndrome ... #secondary #systemic ... #generalized #dermatology

Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear

extramedullary disease ... - infiltrates (anemia ... CLL -> Invade Skin ... #Leukemia #Hematology ... #Oncology #Diagnosis

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