12 results
Algorithm for workup of thrombocytopenia based on observation of the peripheral blood film. 
TTP/HUS indicates thrombotic
thrombocytopenic purpura ... /hemolytic uremic ... syndrome. ... thrombocytopenia, Hematology ... #Diagnosis #Differential
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... leakage of RBC's secondary ... DIC/TTP/HUS - Hemolytic ... Diagnosis #hematology ... #nonpalpable #dermatology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
) - HELLP syndrome ... thrombocytopenic purpura ... uremic syndrome ... Extravascular #Causes #differential ... #diagnosis #hematology
Petechial/Purpuric Rashes- THE ALGORITHMIC APPROACH 

These rashes can be especially challenging and are
associated with devastating differential
with devastating differential ... vasculitic diseases secondary ... require emergent evaluation ... palpable, the differential ... #Diagnosis #Dermatology
Causes of Thrombocytosis - Differential Diagnosis
Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis):
 • Acute infection
 • Solid organ
Diagnosis Secondary ... iron deficiency, hemolysis ... Myelodysplastic syndrome ... Diagnosis #Causes #hematology ... #secondary
Petechiae/Purpura - Diagnostic Algorithm. Pathophysiology: 1) Represent the passage of erythrocytes from the intravascular to extravascular
Petechiae/Purpura ... Pathophysiology: ... of primary or secondary ... #Diagnosis #Dermatology ... Palpable #Algorithm #Differential
Vasculitis Involving the Skin - Differential Diagnosis Framework

Primary: 50% Cutaneous Vasculitis: Leukocytoclastic Vasculitis
Secondary: CTD: SLE, RA
Involving the Skin - Differential ... Leukocytoclastic Vasculitis Secondary ... Petechiae, Palpable purpura ... Disease • Cogan syndrome ... Vasculitis #skin #dermatology
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura

Activity of von Willebrand factor-cleaving protease activity - A
TTP - Laboratory Evaluation ... Thrombocytopenic Purpura ... hemorrhage and hemolysis ... WBC count and differential ... Diagnosis #Workup #Hematology
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
AIHA Primary Secondary ... lymphoproliferative disorder Secondary ... Cold Agglutinin Syndrome ... younger pts) Differential ... #anemia #hematology
Refeeding Syndrome Overview

What Is It?
	• Electrolyte/fluid shifts caused by initiation of nutrition in severely malnourished patient.
severe clinical complications ... • Seizures • Hemolysis ... hyperparathyroidism • Secondary ... #Nutrition #Differential ... #Diagnosis #Pathophysiology