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diagnosis differential injury alkaline alp ascites lfts pbc phosphatase primary abnormal acute albumin cholangitis dili disease druginduced elevated elevation fatty
Common Etiologies of Cirrhosis Inflammation - Hepatitis B (15 percent) - Hepatitis C (47 percent) - Schistosomiasis
Etiologies of Cirrhosis ... congenital - Primary biliary ... Nonalcoholic fatty liver ... #Differential #Hepatology ... #Cirrhosis #Causes
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 Hepatomegaly - Differential Diagnosis Algorithm Malignant • Primary Carcinoma • Metastases • Lymphoma • Leukemia • Polycythemia
Differential Diagnosis Algorithm ... Non-Malignant • Fatty Liver ... Cholangitis • Primary Biliary ... Cirrhosis #Hepatomegaly ... #Causes #Hepatology
Primary Biliary Cirrhosis - Diagnosis Algorithm Symptoms: Fatigue, Pruritus, Right upper quadrant discomfort Signs: Jaundice, Xanthelasmata, Hepatomegaly Associated history:
Primary Biliary ... Cirrhosis - Diagnosis ... Algorithm Symptoms ... Liver biopsy findings ... #Algorithm #hepatology
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Elevated Liver Enzymes ... Infiltrative • Cirrhosis ... Duct Stone • Biliary ... Others #LFTs #Hepatology ... #Causes
Diagnosis of ascites according to the serum ascites albumin gradient (SAAG) SAAG ≥ 1.1: - Ascitic protein
protein ≤ 2.5 g/dL: Cirrhosis ... syndrome, Massive liver ... syndrome SAAG < 1.1: Biliary ... albumin #gradient #hepatology ... differential #diagnosis #algorithm
Causes of Ascites - Differential Diagnosis Algorithm Portal Hypertension - Prehepatic: • Portal vein thrombosis • Splenic
Causes of Ascites ... - Hepatic: • Cirrhosis ... disease • Acute liver ... failure • Primary biliary ... #Hepatology #causes
Portal Hypertension - Differential Diagnosis Portal Pressure = the pressure difference between the pressure in the portal
Post-Hepatic: • Cardiac causes ... sarcoidosis) • Liver ... metastasis • Fatty liver ... pregnancy • Primary biliary ... #hepatology
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
Causes of Acute ... hepatitis, Acute biliary ... Extrahepatic • Biliary ... #Acute #algorithm ... #hepatology
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm ALP: - Enzymes that catalyze hydrolysis of organic phosphate
Differential Diagnosis Algorithm ... Highest • Bone • Liver ... Intestine - Other causes ... PSC - Other biliary ... #hepatology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
Stepwise Diagnosis Algorithm ... for alternative causes ... Benign/malignant biliary ... obstruction, Primary biliary ... #hepatology
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