10 results
Hypereosinophilia and Hypereosinophilic Syndrome

 • Secondary Hypereosinophilic Syndrome
 • Clinically Relevant HES Variants
 • When to
Syndrome • Secondary ... suspect underlying hematologic ... disorders • Diagnosis ... and Treatment Algorithm ... Syndrome #HES #Hematology
Hair Loss (Alopecia) - General (Diffuse and Focal) Differential Diagnosis Algorithm

DIFFUSE
Scarring - Irreversible-biopsy required
 • Lupus
Differential Diagnosis Algorithm ... decalvans - Secondary ... to Skin Disease ... Congenital hair shaft ... #Diagnosis #Algorithm
Focal / Localized Hair Loss (Alopecia) - Differential Diagnosis Algorithm

Scarring - Irreversible-biopsy required
 - Infectious
Differential Diagnosis Algorithm ... decalvans - Secondary ... to Skin Disease ... Congenital hair shaft ... Focal #Localized #dermatology
Eosinophil Disorders Testing Algorithm
INDICATIONS FOR TESTING:
 • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
Eosinophil Disorders ... Testing Algorithm ... • Screen for secondary ... symptoms (eg, skin ... #diagnosis #hematology
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
purple, hemorrhagic skin ... leakage of RBC's secondary ... Thrombocytopenia: ITP • Secondary ... Differential #Diagnosis #hematology ... #rheumatology #
Cryofibrinogenemia Summary

Cryofibrinogenemia Epidemiology:
 • 40-70 years with a modest female predominance

Cryofibrinogenemia:
 • The precipitation of a
Vascular reactivity (Skin ... cryoglobulinemia Associated Disorders ... Warfarin-induced skin ... Cryofibrinogenemia #diagnosis #rheumatology ... #hematology
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
- Purpura - Skin ... hematological disorders ... reticularis & skin ... Type III Often Secondary ... classification #rheumatology
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
3rd Decade Skin ... and permanent alopecia ... Non-autoimmune rheumatologic ... • Nonscarring alopecia ... Erythematosus #Diagnosis #Rheumatology
Causes of Petechial Rash - Differential Diagnosis Algorithm

Pinpoint areas (less than 2 mm) of hemorrhage, which
Differential Diagnosis Algorithm ... in primary or secondary ... Vasculitis - Collagen disorders ... cryoglobulins • Skin ... #Causes #dermatology
Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
are a group of disorders ... just beneath the skin ... DDX: Rule Out Secondary ... Neutropenia • Platelet Disorders ... Syndromes #diagnosis #hematology