8 results
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
- Differential Diagnosis ... and Workup History ... (CVID, WAS), (neurologic ... psychiatric changes), high ... #hematology
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
immature blasts and high ... hydration - Hyperkalemia ... unless worrisome EKG ... Syndrome #TLS #diagnosis ... #management #hematology
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Disease, PRES Pathophysiology ... Lumbar Puncture, EEG ... Induction Rx: high-dose ... Erythematosus #SLE #CNS #neurology ... #rheumatology #
Summary of Oncologic Emergencies

Neutropenic fever:
- Fever + ANC < 500 → start cefepime ± vancomycin (if
full infectious work-up ... days → add fungal work-up ... syndrome): - Hematologic ... plasmapheresis Hypercalcemia ... #HemeOnc #Diagnosis
Stiff Person Syndrome (SPS) - Diagnosis and Management Summary

Epidemiology:
 • Prevalence: 1-2 cases per million -
Person Syndrome Pathophysiology ... , diaphoresis, high ... : • High index ... antibody that works ... Management #treatment #neurology
Low Alkaline Phosphatase - Hypophosphatasia 

Is Low Alkaline Phosphatase Of Clinical Importance?

ALP enzyme- Discovered in 1923
Low
fractures of feet, thigh ... collection with EDTA Pathophysiology ... respiratory failure • Neurologic ... Hyperlipidemia - Hypercalcemia ... Hyophosphatasia #hepatology
Hepatorenal Syndrome (HRS)

Definition:
• Functional, potentially reversible kidney impairment.
• Occurs in advanced liver disease: cirrhosis, severe alcoholic
Pathophysiology: ... liver insult (e.g ... Prognosis: • High ... Hepatorenal #Syndrome #Hepatology ... #Nephrology #Diagnosis
Solitary Cell Plasmacytoma

What?
• Plasma cell neoplasms can present as a single lesion (solitary plasmacytoma)
• In 3%
red bone marrow, e.g ... CRAB - no anemia, hypercalcemia ... #Plasmacytoma #Oncology ... #Diagnosis #Workup ... #Hematology