41 results
Pathophysiology of Tumor Lysis Syndrome (TLS)
Tumor Cell Lysis
-> Release of DNA
 • Purines -> Hypoxanthine /
Pathophysiology ... Lysis Syndrome (TLS ... -> Allantoin (High ... • Hyperkalemia ... #Pathophysiology
Classification of Tumor Lysis Syndrome (TLS) and Treatment of Metabolic Abnormalities of TLS
Laboratory TLS:
 • Uric
Lysis Syndrome (TLS ... other symptomatic hypocalcemia ... hydroxide • Hyperkalemia ... treatment • Hypocalcemia ... #diagnosis #management
Emergency Management of Hyperkalemia in Adults
Assess Patient - Airway Breathing Circulation Disability Exposure (ABCDE) Approach
 •
Emergency Management ... of Hyperkalemia ... Gluconate IV Shift ... Consider cause of hyperkalaemia ... recurrence #Hyperkalemia
“H’s & T’s“ - The reversible causes of Cardiac Arrest 
Hypovolemia, Hypoxia/Hypoxemia, Hydrogen Ion Excess (Acidosis),
“H’s & T’s“ - The ... Excess (Acidosis), Hypokalemia ... /Hyperkalemia, Hypothermia ... diagnosis #arrest #management
Tumor lysis syndrome refers to the constellation of metabolic disturbances that occurs when large numbers of
hyperuricemia, #hyperkalemia ... hyperphosphatemia, #hypocalcemia ... acutekidneyinjury #Pathophysiology ... #Presentation #TLS
Mechanisms of Drug-Induced Hyperkalemia 
 • Direct renin inhibitor (Aliskiren)
 • Renin release inhibition (NSAIDs, Beta-Blockers)
of Drug-Induced Hyperkalemia ... • Increased EC shift ... MunerMohamed1 #hyperkalemia ... differential #diagnosis #pathophysiology
Hyperkalemia Differential Diagnosis Algorithm
R/O Pseudo-hyperkalemia:
 • Possible Lab error! Alwavs Repeat Blood sample!
 • Leukocytosis, Thrombocytosis:
Hyperkalemia Differential ... Algorithm R/O Pseudo-hyperkalemia ... TTKG should be high ... plasma [K+] #Hyperkalemia ... #pathophysiology
Causes of Hyperkalemia - Differential Diagnosis Framework
 • Cellular Shift:
   - Exercise
Causes of Hyperkalemia ... Framework • Cellular Shift ... Hemolysis • Pseudo hyperkalemia ... Medicine @ucsdim #Hyperkalemia ... Causes #potassium #high
Hyperkalemia - Differential Diagnosis Framework

PseudoHyperkalemia:
 • Lab error
 • Traumatic venipuncture
 • Hemolysis, thrombocytosis, leukocytosis
 •
Hyperkalemia - Differential ... Suspicion for Hyperkalemia ... Drugs Causing Hyperkalemia ... Metabolic acidosis - Hyperkalemia ... cantaloupe #hyperkalemia
Hyperkalemia Management Algorithm
 • Treat the cause & optimize hemodynamics and ventilation
 • Reconsider treatment leadingto
Hyperkalemia Management ... treatment leadingto hyperkalemia ... Intracellular K+ Shift ... / Removal #Hyperkalemia ... treatment #potassium #high