13 results
Pathophysiology of Tumor Lysis Syndrome (TLS)
Tumor Cell Lysis
-> Release of DNA
 • Purines -> Hypoxanthine /
Pathophysiology ... Lysis Syndrome (TLS ... -> Allantoin (High ... • Hyperkalemia ... #Pathophysiology
Causes of Hyperkalemia - Differential Diagnosis Framework
 • Cellular Shift:
   - Exercise
Causes of Hyperkalemia ... Framework • Cellular Shift ... Hemolysis • Pseudo hyperkalemia ... Medicine @ucsdim #Hyperkalemia ... Causes #potassium #high
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... immature blasts and high ... hydration - Hyperkalemia ... #diagnosis #management ... #hematology
Hyperkalemia Management Algorithm
 • Treat the cause & optimize hemodynamics and ventilation
 • Reconsider treatment leadingto
Hyperkalemia Management ... treatment leadingto hyperkalemia ... Intracellular K+ Shift ... / Removal #Hyperkalemia ... treatment #potassium #high
Hyperkalemia - Management Algorithm
 • IV calcium
 • IV insulin and glucose and/or salbutamolt
 • Consider
Hyperkalemia - Management ... blocks, QRS axis shift ... , asystole #hyperkalemia ... #potassium #high ... #diagnosis #management
Tumor Lysis Syndrome
An acute, life-threatening condition that appears within 7 days of starting cytotoxic therapies in
treatments) occur in high ... 6L/day) • For hyperkalemia ... otherwise treat with "hyperkalemia ... Lysis #Syndrome #TLS ... #oncology #management
Rhabdomyolysis - Differential Diagnosis Framework and Management Summary

Causes of Rhabdomyolysis:
 • Trauma:
	- Immobilization
	- Crush injury
	- Compartment
Framework and Management ... • LDH ↑ • Hyperkalemia ... /Late - Hypercalcemia ... Shift of extracellular ... Dialysis for severe hyperkalemia
Rhabdomyolysis - Differential Diagnosis and Management Summary

Trauma:
 • Immobilization, Crush iniury, Compartment syndrome, Electrical injury
Exertional:
 •
Diagnosis and Management ... HIV, Influenza, TSS ... Dermatomyositis) AKI - Pathophysiology ... Shift of extracellular ... Dialysis for severe hyperkalemia
Hyperkalemia Management
Pseudohyperkalemia: 1. Hemolyzed sample 2. Blood drawn from a site/line where potassium or TPN is
Hyperkalemia Management ... minutes-hour) -Shift ... @AnnKumfer #Hyperkalemia ... #Management #treatment ... #potassium #high
Sarcoidosis - Diagnosis and Management Summary
Epidemiology
1) High incidence in Scandinavian countries (11-24 cases per 100,000 individuals
Diagnosis and Management ... Epidemiology 1) High ... survival is 93-95% Pathophysiology ... hyperphosphatemia, hypercalcemia ... Sarcoidosis #Diagnosis #Management