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Causes of Hyperkalemia

Hyperkalemia is caused by excess potassium intake, impaired potassium excretion, or transcellular shifts. The
Causes of Hyperkalemia ... Hyperkalemia ... transcellular shifts ... The etiology of hyperkalemia ... #Hyperkalemia #
Causes of Hyperkalemia - Differential Diagnosis Algorithm
 • Increased Intake
 • Reduced Excretion (IV potassium with
Causes of Hyperkalemia ... - Differential Diagnosis ... Excretion (IV potassium ... Transcellular Shift ... #Hyperkalemia
Hyperkalemia: Diagnostic algorithm
Decreased renal potassium excretion
 • Acute renal failure
 • Chronic renal failure
 • Drugs
Increased
Hyperkalemia: Diagnostic ... • Congenital adrenal ... Addison's/congenital adrenal ... • Type 1 #Hyperkalemia ... #Diagnosis #algorithm
Causes of Hypercalcemia
Hypercalcemia due to increased bone Ca2+ resorption:
 • Primary hyperparathyroidism, Malignancy, Pseudohyperparathyroidism, Renal failure,
Causes of Hypercalcemia ... Hypercalcemia ... Immobilization Hypercalcemia ... #differential #diagnosis ... calcium #high #endocrinology
Hyperkalemia Treatment Options
Stabilize cardiac membrane:
 • IV Calcium (peaks 5-10 minutes)
Decrease potassium concentration:
 • IV Fluids
Shift
Hyperkalemia Treatment ... minutes) Decrease potassium ... • IV Fluids Shift ... (if preserved renal ... LouLectures #Hyperkalemia
Mechanisms of Drug-Induced Hyperkalemia 
 • Direct renin inhibitor (Aliskiren)
 • Renin release inhibition (NSAIDs, Beta-Blockers)
of Drug-Induced Hyperkalemia ... • Increased EC shift ... MunerMohamed1 #hyperkalemia ... #differential #diagnosis ... #pathophysiology
Hypercalcemia - Differential Diagnosis Algorithm
Primary Hyperparathyroidism
 • Adenoma
 • Hyperplasia
 • MEN 1 and 2A
Tertiary Hyperparathyroidism
Hypercalcemia - ... Hyperparathyroidism • Hypercalcemia ... Hypocalciuria Hypercalcemia ... Immobilization • Adrenal ... Paget's Disease #Hypercalcemia
Hypokalemia - Differential Diagnosis Algorithm

Transcellular Shift:
 • Alkalosis
 • ↑ beta-2 adrenergic simulation 
 • Erythropoiesis
Hypokalemia - Differential ... Diagnosis Algorithm ... Transcellular Shift ... Transcellular shifts ... nephrology #low #potassium
Hyperkalemia - Differential Diagnosis Framework

PseudoHyperkalemia:
 • Lab error
 • Traumatic venipuncture
 • Hemolysis, thrombocytosis, leukocytosis
 •
Hyperkalemia - Differential ... Suspicion for Hyperkalemia ... Drugs Causing Hyperkalemia ... Metabolic acidosis - Hyperkalemia ... cantaloupe #hyperkalemia
Hyperkalemia Differential Diagnosis Algorithm
R/O Pseudo-hyperkalemia:
 • Possible Lab error! Alwavs Repeat Blood sample!
 • Leukocytosis, Thrombocytosis:
Hyperkalemia Differential ... R/O Pseudo-hyperkalemia ... plasma [K+] #Hyperkalemia ... Algorithm #causes #potassium ... #high #pathophysiology