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diagnosis treatment differential algorithm cardiology comparison foamed nephrology rhabdomyolysis table aldosterone angiotensin binders chf clinical crystalloids digoxin effects evaluation heartfailure
Potassium-Binding Agents to Treat Hyperkalemia Sodium zirconium cyclosilicate (Lokelma): • Mechanism: Preferentially captures K in exchange for
Potassium-Binding ... Agents to Treat Hyperkalemia ... to moderate); hypokalemia ... Hypomagnesemia; hypokalemia ... #Binding #Hyperkalemia
Hyperkalemia Management Algorithm • Treat the cause & optimize hemodynamics and ventilation • Reconsider treatment leadingto
Hyperkalemia Management ... • Treat the cause ... treatment leadingto hyperkalemia ... Intracellular K+ Shift ... / Removal #Hyperkalemia
Digoxin Pharmacology and Pathophysiology 1) Na/K ATPase Pump - Digoxin works by directly binding to and inhibiting
Digoxin Pharmacology ... works by directly binding ... intracellular calcium causes ... - Hyperkalemia ( ... , in states of hypokalemia
Evaluation and Management of Hypokalemia Hypokalemia is often asymptomatic. Evaluation begins with a search for warning signs
of Hypokalemia ... search for warning signs ... Most cases of hypokalemia-induced ... transcellular shifts ... depletion impedes potassium
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 Here’s a review of the Renin-Angiotensin-Aldosterone system (RAAS) This is a very common pathway that clinicians should
sodium, which causes ... inhibiting drug classes ... this pathway, ending ... avoid harmful hyperkalemia ... ReninAngiotensinAldosteroneSystem #RAAS #Pharmacology
Rhabdomyolysis - Differential Diagnosis Framework and Management Summary Causes of Rhabdomyolysis: • Trauma: - Immobilization - Crush injury - Compartment
Summary Causes ... • LDH ↑ • Hyperkalemia ... Shift of extracellular ... Monitor potassium ... Dialysis for severe hyperkalemia
Hyperkalemia - Diagnosis and Management - GrepMed Handbook S/Sx: Most pts asymptomatic. Weakness, cramping, nausea, paresthesias, palpitations,
Hyperkalemia - Diagnosis ... only if no clear cause ... emcrit.org/ibcc/hyperkalemia ... of hyperkalemia ... #Hyperkalemia
Rhabdomyolysis - Differential Diagnosis and Management Summary Trauma: • Immobilization, Crush iniury, Compartment syndrome, Electrical injury Exertional: •
Diagnosis and Management ... Shift of extracellular ... Monitor potassium ... Dialysis for severe hyperkalemia ... #Summary #causes
Heat Illnesses and Heat Stroke - Differential Diagnosis Framework Heat Cramps: • Muscle pain or spasm -
Loss of sodium/Potassium ... → Syncope • Signs ... Hypoglycemia - Hypocalcemia ... - Hyperkalemia ... differential #diagnosis #causes
Lactated Ringers (LR) vs Normal Saline (NS) - Comparison Composition of LR: • Sodium 130 mEq/L •
130 mEq/L • Potassium ... Is Dangerous in Hyperkalemia ... transcellular shift ... • Saline Causes ... NS #comparison #pharmacology
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