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diagnosis differential nephrology causes hyperkalemia high treatment comparison hematology product reactions rhabdomyolysis table aceinhibitor aceis angiotensinii arb crrt druginduced edema
Mechanisms of Drug-Induced Hyperkalemia • Direct renin inhibitor (Aliskiren) • Renin release inhibition (NSAIDs, Beta-Blockers)
• Increased EC shift ... Benyzlpenicillin, blood ... differential #diagnosis #pathophysiology ... #pharmacology # ... potassium #medications
Hyperkalemia Treatment Options Stabilize cardiac membrane: • IV Calcium (peaks 5-10 minutes) Decrease potassium concentration: • IV Fluids Shift
Hyperkalemia Treatment ... • IV Fluids Shift ... peaks 1-2h) • Blood ... LouLectures #Hyperkalemia ... #management #potassium
ACEI Antihypertensive Dose Comparison. Consider divided (BID) regimen for better pre-dose (trough) BP control for the
Monitor BP, potassium ... ACEInhibitor #ACEIs #Dosing ... #Conversion #Pharmacology ... #Hypertension #Management
Hyperkalemia - Differential Diagnosis Framework PseudoHyperkalemia: • Lab error • Traumatic venipuncture • Hemolysis, thrombocytosis, leukocytosis •
Clenching of fist during ... Crush injury • Blood ... • Recent IV potassium ... Intracellular Shift ... Blood transfusion
Hyperkalemia - Differential Diagnosis Framework PseudoHyperkalemia: • Lab error • Traumatic venipuncture • Hemolysis, thrombocytosis, leukocytosis •
Clenching of fist during ... Crush injury • Blood ... • Recent IV potassium ... Intracellular Shift ... Blood transfusion
Rhabdomyolysis - Differential Diagnosis and Management Summary Trauma: • Immobilization, Crush iniury, Compartment syndrome, Electrical injury Exertional: •
Diagnosis and Management ... Dermatomyositis) AKI - Pathophysiology ... Shift of extracellular ... Monitor potassium ... Dialysis for severe hyperkalemia
Gitelman Syndrome Overview What? • Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter • Gitelman's syndrome
salt-losing tubulopathies ... Normal or low blood ... (renal potassium ... diagnosis #nephrology #management ... #pathophysiology
Rhabdomyolysis - Differential Diagnosis Framework and Management Summary Causes of Rhabdomyolysis: • Trauma: - Immobilization - Crush injury - Compartment
Framework and Management ... UA positive for blood ... Shift of extracellular ... Monitor potassium ... Differential #Diagnosis #Management
ANGIOTENSIN II RECEPTOR ANTAGONIST (ARB) DOSING: TOOL FOR SWITCHING BETWEEN AGENTS IN CANADA The information provided is intended
ANTAGONIST (ARB) DOSING ... monitoring of blood ... pressure, potassium ... ReceptorBlocker #Pharmacology ... #Conversion #Switching
Lactated Ringers (LR) vs Normal Saline (NS) - Comparison Composition of LR: • Sodium 130 mEq/L •
130 mEq/L • Potassium ... Can give with blood ... Is Dangerous in Hyperkalemia ... transcellular shift ... NS #comparison #pharmacology
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