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diagnosis differential hyperkalemia management nephrology pharmacology algorithm anthracycline cardiotoxicity complexes effects hematology her2 lactated leukostasis lr lysis normal ns oncology
Hyperkalemia Management Algorithm • Treat the cause & optimize hemodynamics and ventilation • Reconsider treatment leadingto
• Treat the cause ... • Reconsider treatment ... and parenteral potassium ... Intracellular K+ Shift ... #potassium #high
Hyperkalemia - Differential Diagnosis Framework PseudoHyperkalemia: • Lab error • Traumatic venipuncture • Hemolysis, thrombocytosis, leukocytosis •
phlebotomy High ... controlled DM • Chemotherapy ... Intracellular Shift ... differential #diagnosis #causes ... #potassium #high
Hyperkalemia - Differential Diagnosis Framework PseudoHyperkalemia: • Lab error • Traumatic venipuncture • Hemolysis, thrombocytosis, leukocytosis •
phlebotomy High ... controlled DM • Chemotherapy ... Intracellular Shift ... differential #diagnosis #causes ... #potassium #high
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
immature blasts and high ... WBC count cause ... - Cytotoxic chemotherapy ... hydration - Hyperkalemia ... tetany or cardiac arrhythmis
Lactated Ringers (LR) vs Normal Saline (NS) - Comparison Composition of LR: • Sodium 130 mEq/L •
Saline (NS) - Comparison ... 130 mEq/L • Potassium ... Is Dangerous in Hyperkalemia ... transcellular shift ... densa receives high
Premature Ventricular Complexes (PVC's) - Summary Framework Why PVCs? Can be the first manifestation of cardiac
Cardiomyopathy • Inherited arrhythmia ... Hypomagnesemia • Hypokalemia ... percent PVCs/day • High ... more intensive treatment ... #differential #cardiology
Management of Anthracyclines and HER2 Antagonist Cardiotoxicity Anthracyclines cause cardiomyopathy: ✖ Reduction in left ventricular ejection fraction
Anthracyclines cause ... peripheral edema, and arrhythmias ... ) and initiate treatment ... Cardiotoxicity #cardiology ... pharmacology #toxicity #chemotherapy
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