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management nephrology causes differential comparison blood hematology medications product reactions rhabdomyolysis summary agonists algorithm binder binding cholinergic diuresis diuretics effects
Potassium-Binding Agents to Treat Hyperkalemia Sodium zirconium cyclosilicate (Lokelma): • Mechanism: Preferentially captures K in exchange for
Potassium-Binding ... patients sensitive to high ... of aspiration #Potassium ... #medications #pharmacology ... #table #comparison
Potassium Binders for Management of Hyperkalemia • SPS - Sodium polystyrene sulfonate • Patiromer (veltassa) •
Potassium Binders ... Management of Hyperkalemia ... #Hyperkalemia # ... treatment #pharmacology ... #table #comparison
Veltassa (Patiromer) MECHANISM: Potassium Binder INDICATION: Treatment of Hyperkalemia FORMULATION: Powder for oral suspension DOSING: 8.4
) MECHANISM: Potassium ... : Treatment of Hyperkalemia ... oral suspension DOSING ... patiromer) is a potassium ... Pharmacology
Hyperkalemia - Management Algorithm • IV calcium • IV insulin and glucose and/or salbutamolt • Consider
• Consider K+ binder ... blocks, QRS axis shift ... #potassium #high ... #diagnosis #management ... #algorithm #treatment
Hyperkalemia - Differential Diagnosis Framework PseudoHyperkalemia: • Lab error • Traumatic venipuncture • Hemolysis, thrombocytosis, leukocytosis •
Diagnosis Framework ... Clenching of fist during ... phlebotomy High ... Intracellular Shift ... #high #nephrology
Hyperkalemia - Differential Diagnosis Framework PseudoHyperkalemia: • Lab error • Traumatic venipuncture • Hemolysis, thrombocytosis, leukocytosis •
Diagnosis Framework ... Clenching of fist during ... phlebotomy High ... Intracellular Shift ... #high #nephrology
Rhabdomyolysis - Differential Diagnosis Framework and Management Summary Causes of Rhabdomyolysis: • Trauma: - Immobilization - Crush injury - Compartment
- Differential Diagnosis ... Shift of extracellular ... fluid/Lactated ringers ... Monitor potassium ... per day until stable
Rhabdomyolysis - Differential Diagnosis and Management Summary Trauma: • Immobilization, Crush iniury, Compartment syndrome, Electrical injury Exertional: •
- Differential Diagnosis ... Shift of extracellular ... Monitor potassium ... per day until stable ... Dialysis for severe hyperkalemia
Lactated Ringers (LR) vs Normal Saline (NS) - Comparison Composition of LR: • Sodium 130 mEq/L •
130 mEq/L • Potassium ... Is Dangerous in Hyperkalemia ... transcellular shift ... densa receives high ... NS #comparison #pharmacology
Summary of actions of some Cholinergic Agonists Bethanechol • Used in treatment of urinary retention • Binds
retention • Binds ... Produces miosis during ... Edrophonium • Used for diagnosis ... Cholinergic #Agonists #Pharmacology ... #Table #Summary
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