10 results
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... , dyspnea, +/- CXR ... WBC >100k, + lab signs ... TLS #diagnosis #management ... #hematology
Prader-Willi Syndrome: Pathogenesis and clinical findings
 • Maternal uniparental disomy: inheriting 2 copies of maternal chromosome
Prader-Willi Syndrome ... =>Prader-Willi Syndrome ... Signs/Symptoms ... , sleep apnea, cor ... #genetics #pathophysiology
Pott's Disease in Tuberculosis - Diagnosis and Management Summary
Epidemiology:
 - Typically from TB endemic areas
 -
Diagnosis and Management ... cases Clinical Signs ... years - May have signs ... decreased reflexes Pathophysiology ... tissue damage - CXR
Bullous Pemphigoid - Diagnosis and Management Summary
Pathophysiology: Autoantibody-mediated damage to epithelial basement membrane -> separation of
Diagnosis and Management ... Summary Pathophysiology ... dermis Clinical Signs ... /Symptoms/Exam findings ... #dermatology
Heart failure with Reduced Ejection Fraction (HFrEF)
Clinical Presentation
1. Typical symptoms: dyspnea, orthopnea paroxysmal noctumal dyspnea, fatigue,
More Specific Signs ... Less Specific Signs ... Chest x-ray: signs ... acute HF → no signs ... of CXR congestion
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Differentiation Syndrome ... ATRA treatment Pathophysiology ... Diagnosis: >3 symptoms ... APML #diagnosis #management ... #hematology #oncology
Sarcoidosis - Diagnosis and Management Summary
Epidemiology
1) High incidence in Scandinavian countries (11-24 cases per 100,000 individuals
Diagnosis and Management ... survival is 93-95% Pathophysiology ... e.g. incidental CXR ... Sarcoidosis #Diagnosis #Management ... #Signs #Symptoms
What is a Boxer’s fracture?? Fracture of the 4th or 5th metacarpal neck
 - Common in
onto the hand Symptoms ... – compartment syndrome ... Management: - ... compromise - Certain radiologic ... Overlying wounds or signs
Behçet's Syndrome
Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy
Epidemiology:
 • Young
Behçet's Syndrome ... meningitis), MCC CNS symptoms ... #diagnosis #management ... #signs #symptoms ... #rheumatology #
Hemophagocytic Lymphohistiocytosis (HLH)
Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
Overwhelming clinical syndrome ... Diagnosis: HLH signs ... and symptoms can ... Lymphohistiocytosis #diagnosis #management ... #treatment #hematology