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diagnosis management differential pathophysiology algorithm disease peds rheumatology sclerosis workup 21hydroxylasedeficiency 21ohd als alzheimersdisease amyotrophic anesthesia anesthesiology arteritis behcet bells
Alzheimer’s Disease: Pathogenesis and Clinical Findings Risk factor for Late Onset Alzheimer's (99% of cases): - Increasing
mutations - Down syndrome ... chromosome 21) Signs ... pathophysiology #geriatrics ... #diagnosis #signs ... #symptoms
Multiple Sclerosis - Summary Multiple Sclerosis (MS) is an autoimmune-mediated neurodegenerative disease of the central nervous system
Examination: • UMN signs ... Clonus, Babinski’s sign ... • Lhermitte’s sign ... pupillary defect SIGNS ... Signs and symptoms
Causes of Peripheral and Central Vertigo PERIPHERAL VERTIGO 1. Benign paroxysmal positional vertigo (BPPV) - Short-lived (typically less
Causes of Peripheral ... without an obvious cause ... (Wallenberg's syndrome ... Syndrome usually ... signs or symptoms
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
high WBC count cause ... Dehydration • Symptoms ... changes, stroke symptoms ... WBC >100k, + lab signs ... organ damage • Treatment
Growth Hormone Excess - Pathogenesis and clinical findings • Acromegaly and gigantism share the same pathophysiology
• Other rare causes ... Carpal Tunnel Syndrome ... Overproduction #diagnosis #signs ... #symptoms #endocrinology
Peri-operative Hyperthermia - Guidelines for Crises in Anaesthesia If prolonged or ≥ 39 C this is a
Treatment depends ... maintained fever CAUSES ... hyperthermia crisis (late sign ... Phaeochromocytoma Neurologic ... #Differential #Causes
Causes of Secondary Hypertension - Workup and Differential Diagnosis Approach (when evaluation should be done): 1. Severe or
hypertension and signs ... heart failure, neurologic ... renal bruit or signs ... Vasculitis • Endocrinologic ... Neurologic disorders
Neuromyelitis Optica (NMO) - Clinical Manifestations • Optic neuritis: Reduced visual acuity, ranging from mild to
involvement: Intractable nausea ... Other brainstem syndromes ... erythematosus, Sjögren syndrome ... Manifestations #diagnosis #neurology ... #symptoms #signs
Myasthenia Gravis Overview Myasthenia Gravis is an autoimmune disorder of the postsynaptic neuromuscular junction. Ab to
muscles: “myasthenic crises ... test - Cogan sign ... - Peek sign ... Myasthenia Crises ... diagnosis #management #neurology
21-Hydroxylase Deficiency (21-OHD): Pathogenesis and Clinical Findings Autosomal recessive mutation in CYP21A2 coding for the enzyme 21-OHase
enzyme 21-OHase causes ... Signs/Symptoms/Complications ... pathophysiology #genetics #endocrinology ... #peds #pediatrics
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