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nephrology algorithm metabolic pathophysiology syndrome acidosis alkalosis hypernatremia hypokalemia management nagma nonaniongap normal urinary urine
Gitelman Syndrome Pathophysiology Gitelman Syndrome is a rare autosomal recessive salt-losing tubulopathy with a prevalence of 1-
prevalence of 1- ... thiazide-sensitive sodium-chloride ... Hypermagnesuria, Hypomagnesemia ... Pathophysiology #nephrology ... #diagnosis
Gitelman Syndrome Overview What? • Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter • Gitelman's syndrome
thiazide-sensitive sodium ... thiazide-sensitive sodium ... alkalosis • Normal or low ... ratio 0.5%) Differential ... #Syndrome #diagnosis
Metabolic Alkalosis - Urinary Chloride Algorithm Cl- responsive metabolic alkalosis • Kidney loss of Cl-
alkalosis • Normal/low ... Bartter syndrome, Gitelman ... syndrome, Hypomagnesemia ... #differential # ... diagnosis
Hypernatremia - Differential Diagnosis Workup Algorithm 1) Check Urine Osmolality: > 600 mOsm/kg - Implies extrarenal mechanism
Diagnosis Workup ... Algorithm 1) ... • Euvolemic (Low ... #Diagnosis #Workup ... #sodium
Normal Anion-Gap Acidosis (NAGMA) - Differential Diagnosis Framework and Workup NAGMA - Chem, ABG or VBG - Calculate Anion
Diagnosis Framework ... and Workup NAGMA ... Chloride Intoxication ... #Diagnosis #Workup ... #nephrology
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