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Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI)

DILI Types:
 • Intrinsic - predictable, dose dependent
Diagnosis and Management ... Liver Injury (DILI ... presentation • Chronic ... #differential # ... #algorithm #gastroenterology
Differential Diagnosis of Acute Kidney Injury 

#Diagnosis #Nephrology #AKI #Acute #KidneyInjury #Causes #Differential #Workup #Algorithm #Ddxof
Differential Diagnosis ... of Acute Kidney Injury ... #Diagnosis # ... Nephrology #AKI ... #Workup #Algorithm
Acute Kidney Injury (AKI) - Differential Diagnosis Framework

PRE-Renal AKI:
 • Hypovolemia
 • Congestion
 • Medications
 •
Acute Kidney Injury ... (AKI) - Differential ... Diagnosis Framework ... Infection-mediated, Drug-induced ... Diagnosis #nephrology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm
DILI suspicion
Features toxic aetiology: Skin involvement, Kidney injury,
Drug Induced Liver ... Stepwise Diagnosis ... Algorithm DILI ... e.g. ascites), Chronic ... #Injury #Diagnosis
Causes of Seizures - Differential Diagnosis Algorithm
Unprovoked - Epilepsy:
 • Focal: Simple, Complex
 • Generalized: Absence,
Diagnosis Algorithm ... , Recreational drugs ... Traumatic brain injury ... #Diagnosis #Algorithm ... #Causes #neurology
Causes of Acute Kidney Injury (AKI) - Differential Diagnosis Algorithm
Acute Kidney Injury (AKI) - Acute increase
of Acute Kidney Injury ... (AKI) - Differential ... Diagnosis Algorithm ... Acute Kidney Injury ... Diagnosis #Algorithm
Causes of Fatigue - Differential Diagnosis Algorithm
Endocrine
 • Hypo/Hyperthyroidism
 • Diabetes
 • Pituitary Insufficiency
 • Adrenal
Causes of Fatigue - Differential ... Diagnosis Algorithm ... Renal Failure • Liver ... Pulmonary Disease Neurologic ... #Diagnosis #Algorithm
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework
Mild (<100-500): 
 • NAFLD
 • Cirrhosis
 •
Tests (LFTs) - Differential ... Diagnosis Framework ... Cirrhosis • Chronic ... 1000): • DILI (Drug-induced ... liver injury)
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines

ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic ... Hepatitis (AAH) Drug-Induced ... Liver Injury (DILI ... Cirrhosis #Hepatology #gastroenterology ... #management #diagnosis
Guide to Acute Kidney Injury (AKI)

What to ask/look for: 
 - HPI, PMH, full ROS
to Acute Kidney Injury ... - TTE/liver fxn? ... #Nephrology #Diagnosis ... #Algorithm #Causes ... #Differential