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diagnosis hematology management cryofibrinogenemia cvid erythematosus gap hypogammaglobulinemia immunodeficiency immunology lupus myopathy myositis protein proteingap sjogrens sle variable vasculitides vasculitis
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Hypocomplementemia • Can cause ... ducts Clinical ... : • 10%-15% Pulmonary ... MALT Lymphoma • Lung ... #Rheumatology #
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
to impaired B-cell ... to 8 years Clinical ... lung disease (GLILD ... DDX - Other causes ... hypogammaglobulinemia #immunology #hematology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Disease Classification ... permanent alopecia Differential ... , dermatomyositis ... rheumatologic diseases ... common • Antihistone
Cryofibrinogenemia Summary Cryofibrinogenemia Epidemiology: • 40-70 years with a modest female predominance Cryofibrinogenemia: • The precipitation of a
Cold insoluble globulin ... associated with autoimmune ... processes: • Systemic ... Antiphospholipid syndrome ... #hematology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
tract, and often causes ... Drug Associated (Commonly ... inflammatory lesions-interstitial ... #diagnosis #rheumatology ... #classification
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
gammopathy, and skin ... ovarian tumors, lung ... gastric tumors • Hematology ... Comment on type ... #diagnosis #hematology
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
Inflammatory Myopathies: Commonly ... ) • Anti-Mi2 (skin ... lung disease Malignancy ... lung disease • ... lung disease •
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