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diagnosis hematology antinxp2 antinxp2dm common cryofibrinogenemia cvid erythematosus gap globulin hodgkins hypogammaglobulinemia immunodeficiency immunology infections infectiousdiseases lupus lymphoma mycobacteria myopathy
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
ducts Clinical ... : • 10%-15% Pulmonary ... MALT Lymphoma • Lung ... #Rheumatology # ... Diagnosis #Management
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
to impaired B-cell ... to 8 years Clinical ... lung disease (GLILD ... DDX - Other causes ... hypogammaglobulinemia #immunology #hematology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
) Suspect: Clinical ... Disease Classification ... permanent alopecia Differential ... , dermatomyositis ... rheumatologic diseases
Nontuberculous Mycobacteria (NTM) Infections Mycobacterial species other than those belonging to the Mycobacterium tuberculosis complex and
status NTM Cause ... Advanced HIV (CD4 cell ... Disease: Clinical ... Disease: • Clinical ... NTM #Infections #differential
Cryofibrinogenemia Summary Cryofibrinogenemia Epidemiology: • 40-70 years with a modest female predominance Cryofibrinogenemia: • The precipitation of a
associated with autoimmune ... thrombophlebitis, pulmonary ... cryoglobulins • Negative causes ... Antiphospholipid syndrome ... #hematology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
tract, and often causes ... inflammatory lesions-interstitial ... episcleritis as well ... #diagnosis #rheumatology ... #classification
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
) • Anti-Mi2 (skin ... lung disease Malignancy ... lung disease • ... lung disease • ... statins - probably caused
Anti-NXP-2 Dermatomyositis What? DM with generalized subcutaneous edema Pts have more myalgias, more severe weakness, and an increased prevalence
Muscle atrophy may cause ... had more severe disease ... #diagnosis #management ... #rheumatology # ... dermatology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
Immunosuppression • Autoimmune ... Hodgkin Lymphoma - Clinical ... number of sites of disease ... #hematology #oncology ... #management
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
gammopathy, and skin ... changes (POEMS syndrome ... ovarian tumors, lung ... gastric tumors • Hematology ... #diagnosis #hematology
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