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diagnosis hematology management common cryofibrinogenemia cvid dermatologic erythematosus gap globulin gpa granulomatosis hypogammaglobulinemia immunodeficiency immunology infectiousdiseases lupus myopathy myositis nontuberculous
Nontuberculous Mycobacteria (NTM) Infections Mycobacterial species other than those belonging to the Mycobacterium tuberculosis complex and
status NTM Cause ... Advanced HIV (CD4 cell ... Disease: Clinical ... Disease: • Clinical ... #differential #
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
ducts Clinical ... : • 10%-15% Pulmonary ... , INC risk PE, Pulmonary ... MALT Lymphoma • Lung ... #Rheumatology #
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
to impaired B-cell ... to 8 years Clinical ... lung disease (GLILD ... DDX - Other causes ... hypogammaglobulinemia #immunology #hematology
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA) Skin involvement in granulomatosis with polyangiitis (GPA) is common and
GPA causes disease ... Rarely dominate the clinical ... reticularis Differential ... • Goodpasture syndrome ... • Giant cell arteritis
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Disease Classification ... permanent alopecia Differential ... , dermatomyositis ... rheumatologic diseases ... fibromyalgia) • Infections
Cryofibrinogenemia Summary Cryofibrinogenemia Epidemiology: • 40-70 years with a modest female predominance Cryofibrinogenemia: • The precipitation of a
associated with autoimmune ... Malignancy • Infections ... thrombophlebitis, pulmonary ... Antiphospholipid syndrome ... #hematology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
tract, and often causes ... inflammatory lesions-interstitial ... to exclude are infections ... #diagnosis #rheumatology ... #classification
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
Tenderness → Consider infectious ... ) • Anti-Mi2 (skin ... lung disease Malignancy ... lung disease • ... lung disease •
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
gammopathy, and skin ... changes (POEMS syndrome ... ovarian tumors, lung ... gastric tumors • Hematology ... #diagnosis #hematology
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