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management diagnosis idsa opportunistic prevention cytomegalovirus differential hemophagocytic histoplasma histoplasmosis hlh immune inflammatory iris lymphohistiocytosis reconstitution rheumatology summary syndrome
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
↑ sIL-2R >2400 Ul ... +: Virus (EBV, CMV ... , HHV8,...), Bacteria ... or biologics (CMV ... immune deficiency, Drugs
IDSA Recommendations for Treating Cytomegalovirus Infections in HIV-AIDS Preventing CMV Disease: • CMV end-organ disease is best
Cytomegalovirus Infections ... intraocular levels of drug ... control of the infection ... until steady state ... #HIVAIDS #pharmacology
IDSA Recommendations for Preventing and Treating Histoplasma Capsulatum Infections in HIV-AIDS Indications for Initiating Primary Prophylaxis: •
Infections in HIV-AIDS ... histoplasmosis (>10 cases ... with ARV (see Table ... IDSA #Prevention #Treatment ... #HIVAIDS #pharmacology
Immune Reconstitution Inflammatory Syndrome - Overview of IRIS What Is IRIS? • A state of hyperinflammatory response that
• A state of hyperinflammatory ... keratitis, iritis • CMV ... unintentional weight loss, nausea ... • Histoplasma capsulatum ... /drug resistance
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