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diagnosis management activation algorithm antibiotic autoimmune causes failure fungal hematology hepatitis hepatology infectiousdiseases injury lesions liver macrophage mas mycoses myopathy
CNS Ring-Enhancing Lesions - Immunocompromised vs Immunocompetent Multiple Ring-Enhancing Lesions: • Toxoplasmosis (CD4 < 100) • Other
Diagnosis- Compatible syndrome ... lesions • 80% with lung ... multiple lesions Infectious ... RingEnhancing #Lesions #Brain ... #differential #
Causes of Antibiotic Failure - Differential Diagnosis Framework Diagnosis: • Non-Infectious: Malignant, Autoimmune, Drug-related (NMS, serotonin syndrome,
Antibiotic Failure - Differential ... NMS, serotonin syndrome ... Tissue penetration (CNS ... (daptomycin in lungs ... thrombophlebitis), HAP, Blood stream
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
nervous system (CNS ... rash) • Heart, lung ... SLE], AOSD) • Infection ... Liver function tests ... Treatment: • Corticosteroids
Mycoses HISTOPLASMOSIS • Inhalation of conidia → Yeast → travel to lymph nodes → spread in body • Bird
pulmonary symptoms • Rheumatologic ... especially the CNS ... MC: CNS CSF: • ... • Sinusitis • Brain ... fever • Septic shock
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Liver Injury - Differential ... Liver Injury: • Infectious ... CA, small cell lung ... extrahepatic source - Tests ... , RBC, kidney, brain
Pulmonary Renal Syndromes - OnePager Summary Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
anti-GBM) Other tests ... confirm DAH, r/o infection ... sparing of the lung ... #differential # ... diagnosis #management #treatment
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
Autoimmune Myositis - Differential ... Tenderness → Consider infectious ... Diagnostic Tests ... RP-ILD), dermato-rheumatologic ... #differential #
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