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Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
- Differential Diagnosis ... - GI tract: abdominal ... : • Behçet Syndrome ... • Cogan Syndrome ... Supply gut -> abdominal
Behçet's Syndrome
Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy
Epidemiology:
 • Young
, small-vessel vasculitis ... ulceration • Ocular ... prick test that can ... ) Differential Diagnosis ... • Nonsurgical abdominal
Vasculitis Involving the Skin - Differential Diagnosis Framework

Primary: 50% Cutaneous Vasculitis: Leukocytoclastic Vasculitis
Secondary: CTD: SLE, RA
- Differential Diagnosis ... Secondary: CTD ... IgM deposits • Nodular ... : • Behcet Disease ... • Cogan syndrome
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
Diagnosis Framework ... Differential Diagnosis ... multiplex • GI tract: Abdominal ... gut involvement, abdominal ... arterial aneurysms can
Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone
• Heavy Chain disease ... Vasculitis) Autoantibodies ... : • WAIHA • CAD ... Sneddon-Wilkinson disease ... #Differential #Diagnosis
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Erythematous, macular ... Differential Diagnosis ... ANCA-associated vasculitis ... Valvular disorders • CAD ... Erythematosus #Diagnosis
Cryofibrinogenemia Summary

Cryofibrinogenemia Epidemiology:
 • 40-70 years with a modest female predominance

Cryofibrinogenemia:
 • The precipitation of a
malignancies, vasculitis ... pulmonary emboli, and ocular ... Cryofibrinogenemia Diagnosis ... Antiphospholipid syndrome ... Cryofibrinogenemia #diagnosis
Sjogren's Syndrome Overview

Epidemiology:
• F > M: 9:1
• 5-6th Decades (can be any age)

Autoimmune exocrinopathy multisystemic disease
5-6th Decades (can ... Diagnosis: • Dry ... gland) biopsy • Ocular ... ) • Cutaneous vasculitis ... : 2% Systemic Vasculitis
Nontuberculous Mycobacteria (NTM) Infections 

Mycobacterial species other than those belonging to the Mycobacterium tuberculosis complex and
infections • Nodular ... Lady Windermere Syndrome ... : • Syndrome of ... and M. fortuitum can ... enzymes, diarrhea, abdominal
Lung Infections in HIV - Differential Diagnosis Framework

Disease by CD4 Count:
Any CD4 Count:
 • Mycobacterium tuberculosis,
- Differential Diagnosis ... Framework Disease ... Pneumonia: • 3 syndromes ... angioinvasive disease ... lymphadenopathy, • Abdominal