18 results
Polyarteritis Nodosa (PAN): Pathogenesis and Clinical Findings

Medical Comorbidities Malignancies (most commonly hairy-cell leukemia)
Immunogenetic Predisposition: patient is
a dysregulated immune ... erythema and/or swelling ... PolyarteritisNodosa #Pathophysiology ... Diagnosis #Signs #Symptoms ... #Vasculitis
Rapidly Progressive Glomerulonephritis (RPGN)
RPGN has three primary pathophysiologic causes differentiated by immunofluorescence

Immune Complex Mediated (granular staining):
three primary pathophysiologic ... immunofluorescence Immune ... Goodpasture's) Pauci-immune ... Glomerulonephritis #Vasculitis ... #differential #
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
- Differential ... Necrotizing, pauci-immune ... respiratory tracts Immune ... Presentation - Systemic Symptoms ... differential #diagnosis
IgA Vasculitis – Henoch Scholein Purpura: Pathogenesis and Clinical Findings

 - Infectious Agents - 50% have
IgA Vasculitis – ... cell-mediated immune ... - Formation of immune ... HenochScholeinPurpura #Pathophysiology ... Diagnosis #Signs #Symptoms
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
Vasculitis - Differential ... Differential Diagnosis ... Presentation: Systemic Symptoms ... • Progressive symptoms ... #Differential #
Highlighted Conditions With Arteritis or Periarteritis of the Coronaries
Takayasu's arteritis:
 - Onset < 40 yrs
 -
yrs - Cranial symptoms ... multiplex ANCA vasculitis ... Leukocytoclastic vasculitis ... Salivary/Lacrimal swelling ... Coronaries #Arteritis #Differential
Vaccine-induced immune thrombotic thrombocytopenia (VITT) is a rare but potentially serious adverse reaction that has been
Vaccine-induced immune ... Symptoms of VITT ... chest pain, leg swelling ... and neurological symptoms ... thrombocytopenia #COVID #pathophysiology
BEE Syndromes - Immune-mediated conditions affecting the brain, eye, and ear

Visual or auditory symptoms in conjunction
BEE Syndromes - Immune-mediated ... Visual or auditory symptoms ... conjunction with symptoms ... ANCA-associated vasculitides ... #inflammatory #differential
Rheumatoid arthritis (RA): Extra-articular manifestations
Skin: 
 • Inflammation of skin (esp. over areas of stress) forms
Nodules • Auto-immune ... Alopecia • Auto-immune ... blood vessels (vasculitis ... RheumatoidArthritis #RA #pathophysiology ... #signs #symptoms
Neurological Manifestations of Tuberculosis
Spinal Arachnoiditis & Polyradiculopathy:
 • Subacute onset of limb weakness, bladder/bowel dysfunction, muscle
narrowing and collapse Immune ... previous neurologic symptoms ... Meningitis • Include: vasculitis ... • Caused by immune ... Tuberculosis #diagnosis #differential