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differential rheumatology management algorithm classification prs pulmonary rapidly renal rpgn sjogrens syndrome syndromes treatment vasculitides
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
three primary pathophysiologic ... causes differentiated ... Purpura Anti-GBM antibodies ... #Vasculitis #differential ... #diagnosis #algorithm
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
proteinuria, rapidly progressing ... • EGPA: - Eosinophilia ... tract, and often causes ... C-ANCA) pattern: antibodies ... #rheumatology #
Pulmonary Renal Syndromes - OnePager Summary Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
Autoimmune ANCA vasculitis ... life-threatening diseases ... EGPA) • Auto-antibodies ... LVEF, pericardial effusion ... Path: rapidly progressive
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Diagnosis Framework ... ) EGPA (Eosinophilic ... Polyangiitis): • Eosinophilia ... tract, and often causes ... #Rheumatology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Hypocomplementemia • Can cause ... thickening or effusion ... ) • Cutaneous vasculitis ... acidosis • NAGMA • Glomerulonephritis ... Nephrogenic DI Hematologic
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