846 results
COVID-19 Life Cycle

#COVID19 #LifeCycle #Timeline #Pathophysiology #Diagnosis
Cycle #COVID19 #LifeCycle ... #Timeline #Pathophysiology
The biotrauma hypothesis of ventilator-induced lung injury. IL = interleukin; PEEP = positive end-expiratory pressure; Pplat
plateau pressure; TNF ... #Pathophysiology
Fig. 1 Pathophysiology of septic myocardial dysfunction. IL interleukin, iNOS induced nitric oxide synthase, PMN polymorphonuclear
Fig. 1 Pathophysiology ... polymorphonuclear cell, TNF ... necrosis factor #Pathophysiology
Hypothermia in Sepsis - Pathophysiology
 • 20% of septic pts → HYPOTHERMIA
 • Increased mortality 62%
Hypothermia in Sepsis - Pathophysiology ... proinflammatory cytokines ↓TNF-α ... Hypothermia #sepsis #pathophysiology
The pathogenesis of idiopathic pulmonary fibrosis. 1 – In an initiating phase, there is lung alveolar
high levels of TGF-β ... cycle of further TGF-β ... growth factor; TGF-β ... growth factor beta; TNF-α ... #IPF #Pathophysiology
Cardiac Myocyte Contractile cycle
 - Ca2+ binds to TnC → TnI is inhibited → conformational change
Ca2+ binds to TnC ... → TnI is inhibited ... the action of TnI ... #Pathophysiology
Anaphylaxis: Pathogenesis
Anaphylaxis is a Type 1 hypersensitivity reaction
While the primary mechanism of anaphylaxis is mast cell
PAF, tryptase, TNF ... #Anaphylaxis #pathophysiology
TNF-alpha Inhibitors

Dr. Ann Marie Kumfer @AnnKumfer

#TNFalpha #Inhibitors #Diagnosis #Differential #Indications
TNF-alpha Inhibitors
Fever - Pyrogen Pathophysiology

EXOGENOUS PYROGEN
 • Bacteria: Lipopolysaccharide components, peptidoglycans and muramyl peptide derivatives, Toxins
 •
Fever - Pyrogen Pathophysiology ... endogenous pyrogen) TNF ... Fever #Fever #Pathophysiology
HIV Pre-Exposure Prophylaxis (PrEP)
1) Available Agents (one pill daily): TDF-FTC, TAF-FTC
2) Who? Adolescents and adults >
one pill daily): TDF-FTC ... , TAF-FTC 2) Who