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oncology monoclonal differential agglutinin chronic cold disease gammopathies gammopathy gap globulin hemolytic leukemia lymphocytic mds multiplemyeloma myelodysplasia myelodysplastic paraproteinemias protein
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
• MGCS • MGRS ... Lymphoma (HCV) • CLL ... (-) hemolytic anemia ... Paraproteinemias #Hematology ... #Differential #Diagnosis
Monoclonal Gammopathy of Undetermined Significance (MGUS) - Summary Framework Hematologic disorder characterized by the presence of either
No evidence of anemia ... insufficiency, Anemia ... to the plasma cell ... #Significance #hematology ... #diagnosis #oncology
Multiple Myeloma and Monoclonal Gammopathies C - HyperCalcemia- calcium > 11 mg/dL / >1 mg/dL the ULN R
40 ml/min A - Anemia ... diseases, CML, ... plasmacytoma, POEMs syndrome ... #Gammopathies #MGUS ... #diagnosis #hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Diagnosis: • ... • Neutropenia, anemia ... • Richter’s Syndrome ... #workup #oncology ... #hematology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Cold Agglutinin Syndrome ... anemia • Cold ... significance (MGUS ... ), CLL, Myeloma ... #hematology #diagnosis
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... count (anemia) ... • Aplastic Anemia ... Workup: • Complete ... #diagnosis #hematology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Albumin > 4) Work-up ... changes (POEMS syndrome ... gastric tumors • Hematology ... anemia • Other ... #hematology
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