24 results
diagnosis differential algorithm endocrinology pathophysiology causes gynecomastia signs symptoms hematology pharmacology urology workup androstenedione aromatase benign bph disorders estradiol hirsutism
Hypogonadism Differential Diagnosis Algorithm • Low testosterone, Normal or low LH, Normal or low FSH -
Algorithm • Low testosterone ... hypogonadism • Normal testosterone ... etiologies • Normal testosterone ... disease • Low testosterone ... Algorithm #Low #Testosterone
Exogenous Testosterone Side Effects • Mood disorder, Depression, Aggression • ↑ Erythropoiesis • Hypogonadism +/-BPH, prostate
Exogenous Testosterone ... #Exogenous #Testosterone
Inhibin < Hypothalamus < GnRH ④ Anterior pituitary FSH LH V Sertoli cells V Leydig cells Paracrine e e → #Testosterone
Paracrine e e → #Testosterone
#LH #Cholesterol t cholesterol desmolase (#thecal cells) V 3ß-hydroxysteroid dehydrogenase Pregnenolone Progesterone 17a-hydroxylase 17-Hydroxypregnenolone 17,20-lyase Dehydroepiandrosterone 3ß-hydroxysteroid dehydrogenase #Androstenedione 17B-hydroxysteroid dehydrogenase FSH V #Testosterone Đ #aromatase (granulosa cells) V #Estradiol
dehydrogenase FSH V #Testosterone
ACTH LH Cholesterol cholesterol desmolase Pregnenolone 17a-hydroxylase 17 Hydroxyregnenolone 17,20-lyase 3B-hydroxysteroid dehydrogenase 3B-hydroxysteroid dehydrogenase 17a-hydroxylase #Progesterone 17-Hydroxyprogesterone 17,20-lyase 21ß-hydroxylase 21ß-hydroxylase 11-Deoxycorticosterone 11-Deoxycortisol 11ß-hydroxylase 11ß-hydroxylase #Cortisol #Dehydroepiandrosterone #DHEA 3ß-hydroxysteroid dehydrogenase 个 #Androstenedione #17B-hydroxysteroid #dehydrogenase #Testosterone #aromatase #FSH #Estradiol #5a reductase #Corticosterone aldosterone synthase #Aldosterone Angiotensin || #Dihydrotestosterone (DHT)
dehydrogenase #Testosterone
Benign Prostatic Hyperplasia: Pathogenesis and Medications Aging -> Increased Testosterone -> Testosterone metabolized into DHT by type
-> Increased Testosterone ... -> Testosterone ... Conversion of testosterone ... pituitary -> Decr Testosterone
Gynecomastia - Differential Diagnosis Algorithm No Testicular Mass on Ultrasound • Adrenal Neoplasm • Increased Extraglomerular Aromatase
Hyperthyroidism Increased Testosterone ... Resistance Decreased Testosterone
Anemia - Underproduction Diagnostic Algorithm - Iron deficiency anemia - Anemia of chronic inflammation - Anemia
TSH, LFTs, +/- testosterone
Gynecomastia - Differential Diagnosis a nd Workup Algorithm Gynecomastia is common in clinical practice, affecting ~50% of males
LFTs, Prolactin, Testosterone
Hirsutism - Differential Diagnosis Algorithm RAPID ONSET Medications • Steroids • Danazol • Progestin Containing Contraceptives Increased Serum Testosterone
Increased Serum Testosterone
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