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diagnosis rheumatology dermatology vasculitis antimda5 antimda5dm antinxp2 antinxp2dm autoimmune encephalitis heat heatstroke illness infections management meningitis myopathy myositis neurology pathophysiology
ANTI-MDA5 DERMATOMYOSITIS Cutaneous manifestations: • Periorbital heliotrope (blue-purple) rash with edema • Erythematous rash on the face, or the
(blue-purple) rash ... • Erythematous rash ... chest (in a V-sign ... ulcerations • Skin ... • Anti-MDA5 DM
Dermatomyositis (DM) and Polymyositis (PM): Pathogenesis and clinical findings Elevated Antinuclear Antibodies: Anti-Jo-1, Anti-OJ, Anti-Mi2, Anti-SRP, Anti-EJ,
Dermatomyositis ... (DM) and Polymyositis ... processes occur in the skin ... -> Heliotrope Rash ... Pathophysiology #Signs
Heat Illnesses and Heat Stroke - Differential Diagnosis Framework Heat Cramps: • Muscle pain or spasm -
Heat Stroke - Differential ... fatigue Heat Rash ... blisters on the skin ... → Syncope • Signs ... Pale and sweaty skin
Anti-NXP-2 Dermatomyositis What? DM with generalized subcutaneous edema Pts have more myalgias, more severe weakness, and an increased prevalence
DM with generalized ... to have typical DM ... (blue-purple) rash ... • Erythematous rash ... Muscle atrophy may cause
CNS Infections - Viral Encephalitis and Bacterial Meningitis - Differential Diagnosis Framework Viral Encephalitis: MCC: Enteroviruses (e.g., coxsackievirus
CNS Infections - ... Herpesviruses (MCC: HSV ... Maculopapular rash ... Acute meningeal signs ... • Uveitis • Rash
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
purpura: Strong sign ... of shoulder and hip ... , mucositis • Rash ... tract, and often causes ... chorioretinitis, CNS
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
Anti-MDA5 (RP-ILD ... ) • Anti-Mi2 (skin ... Symptoms: • Gottron rash ... elevated < PM and DM ... statins - probably caused
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