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diagnosis rheumatology dermatology management neurology vasculitis antimda5 antimda5dm antinxp2 antinxp2dm autoimmune encephalitis heat heatstroke illness infections meningitis myelitis myositis pathophysiology
ANTI-MDA5 DERMATOMYOSITIS Cutaneous manifestations: • Periorbital heliotrope (blue-purple) rash with edema • Erythematous rash on the face, or the
(blue-purple) rash ... • Erythematous rash ... chest (in a V-sign ... ulcerations • Skin ... • Anti-MDA5 DM
Dermatomyositis (DM) and Polymyositis (PM): Pathogenesis and clinical findings Elevated Antinuclear Antibodies: Anti-Jo-1, Anti-OJ, Anti-Mi2, Anti-SRP, Anti-EJ,
Dermatomyositis ... (DM) and Polymyositis ... processes occur in the skin ... -> Heliotrope Rash ... Pathophysiology #Signs
Heat Illnesses and Heat Stroke - Differential Diagnosis Framework Heat Cramps: • Muscle pain or spasm -
Heat Stroke - Differential ... fatigue Heat Rash ... blisters on the skin ... → Syncope • Signs ... Pale and sweaty skin
Anti-NXP-2 Dermatomyositis What? DM with generalized subcutaneous edema Pts have more myalgias, more severe weakness, and an increased prevalence
DM with generalized ... to have typical DM ... (blue-purple) rash ... • Erythematous rash ... Muscle atrophy may cause
CNS Infections - Viral Encephalitis and Bacterial Meningitis - Differential Diagnosis Framework Viral Encephalitis: MCC: Enteroviruses (e.g., coxsackievirus
CNS Infections - ... Herpesviruses (MCC: HSV ... Maculopapular rash ... Acute meningeal signs ... • Uveitis • Rash
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
Anti-MDA5 (RP-ILD ... ) • Anti-Mi2 (skin ... Symptoms: • Gottron rash ... elevated < PM and DM ... statins - probably caused
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
purpura: Strong sign ... of shoulder and hip ... , mucositis • Rash ... tract, and often causes ... chorioretinitis, CNS
Transverse Myelitis Overview Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
that results in CNS ... • Bilateral signs ... - Pleocytosis: Mild ... simplex virus, HIV, Hep ... management #neurology #differential
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