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dermatology blood dermatomyositis differential hematology product reactions adult antimda5 antimda5dm antinxp2 antinxp2dm aosd arteritis autoimmune disease dress gca giantcell myopathy
ANTI-MDA5 DERMATOMYOSITIS Cutaneous manifestations: • Periorbital heliotrope (blue-purple) rash with edema • Erythematous rash on the face, or the
(blue-purple) rash ... • Erythematous rash ... chest (in a V-sign ... Dermatomyositis #rheumatology ... #dermatology #diagnosis
Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Definition: • Severe adverse drug reaction, characterized by
rash in association ... • Maculopapular ... Edema in 70% of cases ... withdrawal • Mild ... #management
Adult Onset Still's Disease Systemic inflammation with urticarial rash. Rash: • Nonpruritic, evanescent (correlates with time of
with urticarial rash ... nonpruritic macular or maculopapular ... skin rash that ... #rheumatology # ... management
Giant cell arteritis (GCA) Giant cell arteritis (GCA) definition: Most common systemic inflammatory vasculitis in older adults
systemic sx + signs ... required due to skip ... (Cornelia NEJM ... them, but urgent rheumatology ... #Management
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
purpura: Strong sign ... , mucositis • Rash ... tract, and often causes ... vesicles, pustules, maculopapular ... #Rheumatology
Blood Transfusion Reactions Immune Mediated: • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
/sx urticaria, maculopapular ... rash, pruritis, ... infections with skin ... #Transfusion #diagnosis ... #management #hematology
Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
/sx urticaria, maculopapular ... rash, pruritis, ... infections with skin ... #Transfusions #diagnosis ... #management #hematology
Anti-NXP-2 Dermatomyositis What? DM with generalized subcutaneous edema Pts have more myalgias, more severe weakness, and an increased prevalence
(blue-purple) rash ... • Erythematous rash ... Muscle atrophy may cause ... Dermatomyositis: • ILD ... #management #rheumatology
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
Anti-MDA5 (RP-ILD ... ) • Anti-Mi2 (skin ... Symptoms: • Gottron rash ... ) • Shawl sign ... statins - probably caused
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