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diagnosis hematology differential oncology leukemia causes chronic globulin lymphocytic mds myelodysplasia myelodysplastic petechiae petechial physicalexam polycythemia protein proteingap rash syndromes
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
, CLL Acute leukemias ... activity • ↓ LAP ... or functional neutropenia ... -> Invade Skin: ... #Leukemia #Hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Hepatomegaly • Skin ... Cytopenias: • Neutropenia ... leukemia #CLL ... Leukemia #diagnosis #workup ... #oncology #hematology
Causes of Petechial Rash - Differential Diagnosis Algorithm Pinpoint areas (less than 2 mm) of hemorrhage, which
Differential Diagnosis Algorithm ... RA, Sjogren's, GPA ... deficiency Work ... cryoglobulins • Skin ... #Causes #dermatology
Polycythemia - Differential Diagnosis Algorithm Polycythemia itself isn’t a diagnosis. Like many things, it is a condition
Differential Diagnosis Algorithm ... Better call hematology ... kidneys) - Some tumors ... you’ll do a good workup ... #workup #hematology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Albumin > 4) Work-up ... myeloma • Plasma cell ... gammopathy, and skin ... • Hematology: ... Thalassemia, Sickle cell
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... just beneath the skin ... Myeloproliferative Disease • Neutropenia ... Workup: • Complete ... Syndromes #diagnosis #hematology
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