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diagnosis syndrome sle treatment differential druginduced erythematosus hemophagocytic hlh lymphohistiocytosis oncology signs systemic activation alkaline autoantibodies behcet cerebritis comparison differentiation
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
CNS Manifestations ... Disease, PRES Pathophysiology ... Erythematosus #SLE #CNS ... #neurology #rheumatology ... cerebritis #diagnosis #management
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Systemic Lupus Erythematosus ... Anti-cardiolipin (aPL ... - Anti-B2GP1 (aPL ... autoantibodies #signs #symptoms ... #differential #rheumatology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
, CML, AML, APML ... involvement • 30%: CNS ... leukostasis syndrome: CNS ... smear: Blasts APML ... #Leukemia #Hematology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Incidence: common in APL ... the study) • Triggers ... ATRA treatment Pathophysiology ... Diagnosis: >3 symptoms ... #hematology #oncology
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... hyperviscosity syndrome • Triggers ... into serum • Triggers ... TLS #diagnosis #management ... #hematology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
Epidemiology: -10% of all ... Constitutional symptoms ... constitutional symptoms ... comparison #table #rheumatology ... #diagnosis #management
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
nervous system (CNS ... SJIA], systemic lupus ... tests ↑ AST ↑ ALT ... Syndrome #Diagnosis #Management ... #Hematology #Rheumatology
Low Alkaline Phosphatase - Hypophosphatasia Is Low Alkaline Phosphatase Of Clinical Importance? ALP enzyme- Discovered in 1923 Low
membrane into the CNS ... collection with EDTA Pathophysiology ... mineralization Symptoms ... respiratory failure • Neurologic ... Hyophosphatasia #hepatology
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
skin injury) • Neurologic ... symptoms (headache ... Syndrome #diagnosis #management ... #signs #symptoms ... #rheumatology #
Hemophagocytic Lymphohistiocytosis (HLH) Treatment Primary HLH: - HLH-94 Protocol • Dexamethasone
(depending on CNS ... varies depending on trigger ... • Almost all patients ... HLH #Treatment #management ... #hematology
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