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differential hematology causes management oncology nephrology testing classification criticalcare disease glomerular macrocytic nephrotic pancytopenia treatment aafp abg abnormal acid acidbase
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... anemia): ... ) - HELLP syndrome ... uremic syndrome ... lymphoproliferative disorders
Hypersensitivity: Summary Type I Hypersensitivity: • Immunological Mediator: lgE • Immunological Target: Allergen Molecules • Ex: Antibiotic
Immunological Mediator: lgE ... thrombocytopenia, Autoimmune Hemolytic ... anemia, Penicillin-induced ... Stevens-Johnson Syndrome ... Classification #Diagnosis
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... Algorithm • Sickle ... Consider RBC membrane disorder ... #Diagnosis #Algorithm ... #workup #hematology
Eosinophil Disorders Testing Algorithm INDICATIONS FOR TESTING: • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
Testing Algorithm ... eosinophilia (common ... causes are asthma ... , allergy, drug ... #diagnosis #hematology
Pancytopenia - Workup and Differential Diagnosis Algorithm Consumption Disorders 1. Autoimmune Mediated Pancytopenia 2. Splenic Sequestration Peripheral Destruction
Pancytopenia - Workup ... Algorithm Consumption ... Disorders 1. ... HLH syndrome 5. ... Acquired Aplastic Anemia
Inherited Non-hemolytic Disorders of Hyperbilirubinemia == Disorders of Conjugation == Gilbert Syndrome: • 5-10% of the population
Inherited Non-hemolytic ... population • Most common ... without evidence of hemolysis ... common Crigler-Najjar ... bilirubin #hepatology #diagnosis
Pancytopenia - Workup and Differential Diagnosis Algorithm Consumption Disorders 1. Autoimmune Mediated Pancytopenia 2. Splenic Sequestration Peripheral Destruction
Pancytopenia - Workup ... Algorithm Consumption ... Disorders 1. ... HLH syndrome 5 ... Acquired Aplastic Anemia
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Cold Agglutinin Syndrome ... symptoms - most common ... • Symptoms of anemia ... Diagnosis: • hemolytic ... anemia • Cold
Alpha-gal Syndrome (AGS) - Diagnosis Algorithm Does patient have recurrent episodes of urticaria, angioedema or isolated GI
Alpha-gal Syndrome ... (AGS) - Diagnosis ... most common ... #AGS #Diagnosis ... #Algorithm #allergy
Anemia Diagnostic Algorithm Mean corpuscular (cell) volume (MCV): Average RBC size. Under 80 = microcytic. Between 80-95
Anemia Diagnostic ... acute blood loss, hemolysis ... (BM) ablative disorders ... #Algorithm #Diagnosis ... #Workup #Hematology
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