22 results
Eosinophil Disorders Testing Algorithm
INDICATIONS FOR TESTING:
 • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
Eosinophil Disorders ... (common causes are ... asthma, allergy ... #Disorders #Algorithm ... #Differential #diagnosis
Eosinophilia - Differential Diagnosis Algorithm
Idiopathic Eosinophilia
Primary Eosinophilia:
 • Primary hypereosinophilic syndrome
 • Eosinophilic Leukemia
 • MPN/MDS
Diagnosis Algorithm ... Genetic: Hyper-lgE ... histiocytosis • Allergic ... #Differential #Diagnosis ... #Algorithm #allergy
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... anemia): ... ) - HELLP syndrome ... uremic syndrome ... lymphoproliferative disorders
Hypersensitivity: Summary
Type I Hypersensitivity:
 • Immunological Mediator: lgE
 • Immunological Target: Allergen Molecules
 • Ex: Antibiotic
Immunological Mediator: lgE ... thrombocytopenia, Autoimmune Hemolytic ... anemia, Penicillin-induced ... Stevens-Johnson Syndrome ... Classification #Diagnosis
Hemolytic Anemia - Differential Diagnosis Algorithm
 • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... Algorithm • Sickle ... Consider RBC membrane disorder ... #Diagnosis #Algorithm ... #workup #hematology
Pancytopenia - Workup and Differential Diagnosis Algorithm
Consumption Disorders
 1. Autoimmune Mediated Pancytopenia
 2. Splenic Sequestration
Peripheral Destruction
Pancytopenia - Workup ... Algorithm Consumption ... Disorders 1. ... HLH syndrome 5. ... Acquired Aplastic Anemia
Penicillin Allergy Pathway for Antibiotic Prescription in Patients With Penicillin Allergy
Mild Reaction - Itching, Minor rash
Stevens-Johnson syndrome ... nephritis, Drug rash eosinophilia ... systemic symptoms syndrome ... , Hemolytic anemia ... #Prescription #algorithm
Pancytopenia - Workup and Differential Diagnosis Algorithm
Consumption Disorders
 1. Autoimmune Mediated Pancytopenia
 2. Splenic Sequestration
Peripheral Destruction
Pancytopenia - Workup ... Algorithm Consumption ... Disorders 1. ... HLH syndrome 5 ... Acquired Aplastic Anemia
Elevated Lactate Dehydrogenase (LDH) - Differential Diagnosis Framework

LDH is a cytoplasmic enzyme present in tissues throughout
- Differential Diagnosis ... paralyses CNS Disorders ... • Tumor lysis syndrome ... Polyarteritis nodosa • Eosinophilic ... #differential #diagnosis
Anemia Diagnostic Algorithm

Mean corpuscular (cell) volume (MCV): Average RBC size. Under 80 = microcytic. Between 80-95
Anemia Diagnostic ... acute blood loss, hemolysis ... (BM) ablative disorders ... #Algorithm #Diagnosis ... #Workup #Hematology