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diagnosis differential management oncology dermatology hepatology knee msk rheumatology algorithm amyloid amyloidosis cirrhosis clinical effusions encephalopathy gammopathies hemeonc hemophagocytic hepatitis
Causes of Bone/Joint Pain in Sickle Cell Disease Vaso-occlusive pain: • Mechanism: ischemic pain • Can present
Causes of Bone/Joint ... Generally affects long bones ... • XR, MRI to ... BrighamChiefs #Bone ... #hematology
SAPHO Syndrome Summary What? SAPHO syndrome is a rare chronic inflammatory disorder of bone, joint, and skin characterized
inflammatory disorder of bone ... • Bone and joint ... Rule out other causes ... - MRI: inflammation ... osteoarticular and skin disease
Multiple Myeloma and Monoclonal Gammopathies C - HyperCalcemia- calcium > 11 mg/dL / >1 mg/dL the ULN R
g/dl LLN B - Bony ... more: • Clonal bone ... focal lesions on MRI ... plasmacytoma, POEMs syndrome ... MGUS #diagnosis #hematology
Osgood-Schlatter Disease - MSK Radiology Imaging Findings: • Infrapatellar fat-pad edema with loss of the patellar tendon
fragmentation and mild bone ... possible secondary ossification ... • MRI is more sensitive ... marrow edema and bony ... patella #clinical #mri
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Drug induced - Bone ... marrow disease ... Kasabach-Merritt syndrome ... Gardner-Diamond syndrome ... Differential #Diagnosis #hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
hypercellular bone ... megakaryocytic Bone ... Aplastic Anemia • Bone ... the blood and bone ... blood smear • Bone
Causes of Knee Effusions - Differential Diagnosis Framework Knee Effusion Red Flags: 1. Fever/Chills/Joint pain/Night sweats/Weight loss - DDX: -
Causes of Knee Effusions ... Seronegative Reactive Syndrome ... Effusions: - Hematologic ... - Aneurysmal bone ... Knee #Effusions #causes
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
blood smear or on bone ... bleeding, infections, bone ... cells - Blood and Bone ... • Headaches, bone ... neutropenia) • Bone
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Algorithm Vascular Causes ... vein: Budd-chiari syndrome ... • Gilbert's syndrome ... hemolysis) • ALP: Bone ... diagnosis #algorithm #hepatology
Posterior Reversible Encephalopathy Syndrome (PRES) Overview Clinico-Radiological Syndrome, characterized by: • Headache • Seizures • Altered mental
Shock, Autoimmune disease ... Transplantation including bone ... Vascular narrowing on MRA ... the underlying cause ... with AEDs until cause
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