22 results
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor
The maturation factor is
• Anemia of chronic ... kidney disease, ... Hypogonadism • Bone ... marrow failure: Aplastic ... Production #Index #hematology
Anemia - Underproduction Diagnostic Algorithm
 - Iron deficiency anemia
 - Anemia of chronic inflammation
 - Anemia
- Anemia of chronic ... - Anemia of chronic ... kidney disease ... deficiency - Probable bone ... Underproduction #Algorithm #hematology
Pancytopenia - Workup and Differential Diagnosis Algorithm
Consumption Disorders
 1. Autoimmune Mediated Pancytopenia
 2. Splenic Sequestration
Peripheral Destruction
Flow cytometry, Bone ... Alcoholism Bone ... FISH • Acquired Aplastic ... Metastatic Disease ... Diagnosis #Algorithm #Hematology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary
myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
dys- (abnormal) -plastic ... • Bone marrow ... Management #treatment #hematology ... #oncology
Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks:	1) Childhood	2) 15-25 years	3) >60 years

What?
• Aplastic anemia
= Hypocellular bone ... • Suggested by bone ... hypoplasia/fatty bone ... #Anemia #oncology ... #hematology #diagnosis
Overall Approach to Anemia - Differential Diagnosis Algorithm

Blood Loss
 • Acute Bleed - Normocytic / Normochromic
RBCs on Smear • Chronic ... Deficiency • Aplastic ... • Anemia of Chronic ... Disease • Marrow ... Algorithm #Causes #Hematology
Pancytopenia - Workup and Differential Diagnosis Algorithm
Consumption Disorders
 1. Autoimmune Mediated Pancytopenia
 2. Splenic Sequestration
Peripheral Destruction
Flow cytometry, Bone ... Alcoholism Bone ... FISH • Acquired Aplastic ... Metastatic Disease ... Diagnosis #Algorithm #Hematology
Multiple Myeloma and Monoclonal Gammopathies
C - HyperCalcemia- calcium > 11 mg/dL / >1 mg/dL the ULN
R
ULN R - Renal disease ... more: • Clonal bone ... chain deposition disease ... MGUS #diagnosis #hematology ... #oncology
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
cells can indicate disease ... Pure red cell aplasia ... Warm AIHA • Bone ... diagnosis #workup #oncology ... #hematology
SAPHO Syndrome Summary

What?
SAPHO syndrome is a rare chronic inflammatory disorder of bone, joint, and skin characterized
syndrome is a rare chronic ... inflammatory disorder of bone ... osteoarticular and skin disease ... SAPHO #Syndrome #Rheumatology ... diagnosis #management #Dermatology