37 results
Osteoporosis: Pathogenesis and risk factors

 • Age > 30 (post-peak bone mass)
 • Post-menopausal women ->
Osteoporosis: Pathogenesis ... 30 (post-peak bone ... Decr estrogen • Bone ... #pathophysiology ... #signs #symptoms
Hyperparathyroidism - Primary vs Secondary vs Tertiary 
Lab Comparison:
 • Primary Hyperparathyroidism: ↑→PTH, ↑Calcium, ↑Vitamin D,
Symptoms: Commonly no signs ... , Fragile bones/ ... osteoporosis, Kidney ... easily/weakness, Bone ... Secondary #Tertiary #pathophysiology
Glucocorticoid-Induced Osteoporosis: Pathogenesis and Clinical Findings

 • Negative feedback on hypothalamus/pituitary, Decreasing ACTH -> Decr Sex
Glucocorticoid-Induced Osteoporosis ... Pathogenesis and Clinical ... -> Reduced Bone ... #pathophysiology ... #signs #symptoms
Gaucher Disease 

Pathophsiology
 • Lysosomal storage disorder
 • Deficiency of ß-glucocerebrosidase
• Accumulation of glucosylceramide in macrophages
Diagnosis
Gaucher Disease Pathophsiology ... in GBA1 gene Clinical ... Osteonecrosis, bone ... infarcts, osteoporosis ... Disease #Diagnosis #Signs
Prader-Willi Syndrome: Pathogenesis and clinical findings
 • Maternal uniparental disomy: inheriting 2 copies of maternal chromosome
Pathogenesis and clinical ... Prader-Willi Syndrome Signs ... Infertility • Decr Bone ... mineral density and osteoporosis ... sleep apnea, cor pulmonale
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations

 • Immune Complex Deposition
    - Arthralgia, Arthritis
Weakness, Incr CK • Bone ... Normal CK • Osteoporosis ... Complications #pathophysiology ... #signs #symptoms
Stress Fracture: Pathogenesis and clinical findings
Abnormal biomechanics, Repetitive impact activities
=> Repetitive subthreshold mechanical loading
=> Bone strain
=>
Pathogenesis and clinical ... mechanical loading => Bone ... strain => Bone ... #orthopedics #pathophysiology ... #symptoms #signs
Lung POCUS: Shred sign in patient with non-translobar consolidation. Phased array probe used.

Dr. Robert Jones @RJonesSonoEM

#ShredSign
Lung POCUS: Shred sign ... Robert Jones @RJonesSonoEM ... #Lung #POCUS #Pulmonary ... #Ultrasound #Clinical
Fat Embolism Syndrome
Trauma to the long bone or pelvis accounts for —9096 of cases. The diagnosis
Trauma to the long bone ... Pathophysiology ... onset widespread pulmonary ... FES is a clinical ... Syndrome #Diagnosis #Signs
Pulmonary Embolism on POCUS Echocardiogram

Mid 30's female with chest pain/dyspnea.  Triage EKG (no prior).
Pulmonary Embolism ... RV, McConnell's sign ... Robert Jones @RJonesSonoEM ... Echocardiogram #A4c #clinical ... cardiology #McConnells #sign