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diagnosis hematology oncology anemia aplastic neurology barre bulimianervosa chronic cll encephalopathy gbs genetics guillain lymphocytic pediatrics peds posterior praderwilli pres
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
rapid onset of symptoms ... chronic onset of symptoms ... develop leukostasis syndrome ... • Tumor lysis syndrome ... Transformation: • Complication
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
with no early symptoms ... Warm AIHA • Bone ... • Richter’s Syndrome ... • GI complications ... • Sezary syndrome
Aplastic Anemia - Illness Script Signs and symptoms: • Recurrent infections from neutropenia • Mucosal bleeding from
Script Signs and symptoms ... with hypocellular bone ... neutropenic fever) Complications ... to MDS or acute leukemia ... Anemia #diagnosis #management
Prader-Willi Syndrome: Pathogenesis and clinical findings • Maternal uniparental disomy: inheriting 2 copies of maternal chromosome
Prader-Willi Syndrome ... Signs/Symptoms ... /Complications: ... Infertility • Decr Bone ... #genetics #pathophysiology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
= Hypocellular bone ... Constitutional Syndromes ... virus (EBV) • Leukemia ... • Improve the symptoms ... hematology #diagnosis #management
Posterior Reversible Encephalopathy Syndrome (PRES) Overview Clinico-Radiological Syndrome, characterized by: • Headache • Seizures • Altered mental
Encephalopathy Syndrome ... Transplantation including bone ... Etiology: • Pathophysiology ... Neurological symptoms ... #diagnosis #management
Guillain-Barré Syndrome (GBS) Acute autoimmune demyelinating polyradiculoneuropathy that presents with rapidly progressive flaccid weakness Epidemiology: • Incidence: 1
Guillain-Barré Syndrome ... surgery, trauma, and bone-marrow ... than one after symptom ... the underlying pathophysiology ... #diagnosis #management
Bulimia Nervosa: Complications GASTROINTESTINAL • Dehydration & inability to digest food -> Constipation • Recurrent vomiting exposes
Bulimia Nervosa: Complications ... • Boerhaave syndrome ... hormone levels cause bones ... #pathophysiology ... diagnosis #signs #symptoms
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