18 results
Low Alkaline Phosphatase - Hypophosphatasia 

Is Low Alkaline Phosphatase Of Clinical Importance?

ALP enzyme- Discovered in 1923
Low
• softening of bones ... of feet, thigh bones ... collection with EDTA Pathophysiology ... mineralization Symptoms ... respiratory failure • Neurologic
Mastoiditis: Pathogenesis and clinical findings

Acute or Chronic Otitis Media -> 
Stage 1: Hyperemeia of the mastoid
3: Necrosis of bone ... inner cortical bone ... #Mastoiditis #pathophysiology ... #signs #symptoms ... #diagnosis #otology
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Triggers: ATRA treatment ... Pathophysiology ... Diagnosis: >3 symptoms ... Renal Failure Treatment ... management #hematology #oncology
Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks:	1) Childhood	2) 15-25 years	3) >60 years

What?
• Aplastic anemia
= Hypocellular bone ... • Suggested by bone ... aplastic anemia Treatment ... • Improve the symptoms ... Aplastic #Anemia #oncology
Posterior Reversible Encephalopathy Syndrome (PRES) Overview

Clinico-Radiological Syndrome, characterized by:
 • Headache
 • Seizures
 • Altered mental
may precede the neurologic ... Transplantation including bone ... Etiology: • Pathophysiology ... Neurological symptoms ... epilepticus Treatment
Bell's Palsy - Diagnosis and Management Summary - GrepMed Handbook

Acute Idiopathic Unilateral Facial Nerve (CN7) Palsy
Presentation:
presentation • Lyme Serology ... Imaging (if atypical symptoms ... middle ear/temporal bone ... Diagnosis #Management #Treatment ... #Neurology
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
with no early symptoms ... microglobulin Treatment ... Warm AIHA • Bone ... diagnosis #workup #oncology
Scurvy (Vitamin C Deficiency) - Diagnosis and Management

Vitamin C is required for hydroxylation of proline residues
Mucous membranes • Bone ... musculoskeletal symptoms ... Psychiatric symptoms ... vasculitis Treatment ... #AscorbicAcid #Pathophysiology
Mycoses

HISTOPLASMOSIS
• Inhalation of conidia → Yeast → travel to lymph nodes → spread in body
• Bird
acute respiratory symptoms ... Rheumatologic symptoms ... by culture or serology ... Aspergillosis Pathophysiology ... Diagnosis: • Serology
Guillain-Barré Syndrome (GBS)
Acute autoimmune demyelinating polyradiculoneuropathy that presents with rapidly progressive flaccid weakness
Epidemiology:
 • Incidence: 1
surgery, trauma, and bone-marrow ... than one after symptom ... the underlying pathophysiology ... and cauda equina TREATMENT ... diagnosis #management #neurology