80 results
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
pylori test (GI symptoms ... candidate) - Bone ... patients if the cause ... or if a primary hematologic ... #Workup #hematology
Causes of Bone/Joint Pain in Sickle Cell Disease
Vaso-occlusive pain:
 • Mechanism: ischemic pain
 • Can present
Causes of Bone/Joint ... Generally affects long bones ... BrighamChiefs #Bone ... differential #diagnosis #causes ... #hematology
Hemolysis - Diagnostic Algorithm and Causes

Increased red cell production: 
 • Increased Reticulocytosis/polychromasia 
 • Erythroid
Algorithm and Causes ... hyperplasia of bone ... #Differential #Causes ... #Workup #Hematology
Molluscum Contagiosum 
Clinical 
 • Most common in school-age children 
 • Transmitted by direct contact
Painless, no systemic symptoms ... extremities • Spares ... Clinical #Management #Dermatology
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
• Secondary Causes ... Drug induced - Bone ... Differential #Diagnosis #hematology ... #rheumatology # ... #nonpalpable #dermatology
Childhood Immunization Schedule: Why we immunize
 • Diphtheria Toxin -> URT inflammation causes pseudomembrane with hardened
Tetanus Toxin -> Spores ... invade URT & via hematologic ... hemorrhagic rash; symptoms ... CNS and hematologic ... lymph -> Koplik's spots
Causes of Leukocytosis and Leukopenia - Differential Diagnosis
 • Eosinophilia (AEC > 500, hypereosinophilia > 1500):
Causes of Leukocytosis ... Drugs, Autoimmune, Bone ... Differential #Diagnosis #causes ... #hematology
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm

ALP:
 - Enzymes that catalyze hydrolysis of organic phosphate
- Highest • Bone ... Intestine - Other causes ... Most common symptoms ... symptoms - Pain ... Diagnosis #Algorithm #hepatology
Eosinophil Disorders Testing Algorithm
INDICATIONS FOR TESTING:
 • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
workup for specific symptoms ... for secondary causes ... eosinophilia (common causes ... organ-specific signs or symptoms ... Differential #diagnosis #hematology
SAPHO Syndrome Summary

What?
SAPHO syndrome is a rare chronic inflammatory disorder of bone, joint, and skin characterized
inflammatory disorder of bone ... anterior chest wall, parts ... Rule out other causes ... SAPHO #Syndrome #Rheumatology ... diagnosis #management #Dermatology