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diagnosis msk differential hepatology management mri oncology alkaline anemia phosphatase abnormal aplastic classification cold comparison disease elevation enzymes essential et
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm ALP: - Enzymes that catalyze hydrolysis of organic phosphate
stimulation (placenta/Bone ... - Highest • Bone ... Renal disease - Bone ... symptoms - Pain ... #hepatology
Low Alkaline Phosphatase - Hypophosphatasia Is Low Alkaline Phosphatase Of Clinical Importance? ALP enzyme- Discovered in 1923 Low
synthesized in: liver, bone ... • softening of bones ... of feet, thigh bones ... : Inhibitor of bone ... Skeletal: - Bone
Fever of Unknown Origin (FUO) - Further Workup • CNS symptoms? Get an LP and imaging
Workup • CNS symptoms ... Returning Traveler’ algorithm ... node biopsy • Clinical ... values supporting hematologic ... Bone marrow biopsy
Monoclonal Gammopathy of Undetermined Significance (MGUS) - Summary Framework Hematologic disorder characterized by the presence of either
level <3 g/dL • Bone ... g/dL • Clonal bone ... insufficiency, Anemia, and Bone ... lesions (CRAB) ... disorder • Clonal bone
Abnormal liver function tests algorithm. This figure details the initial response to abnormal liver blood tests.
function tests algorithm ... symptoms/signs ... ALP, alkaline phosphatase ... LFTs #Abnormal #Algorithm ... #Hepatology #Liver
Paget’s Disease: Pathogenesis and Clinical Findings • Incr serum CTx - marker of bone resorption •
Pathogenesis and Clinical ... CTx - marker of bone ... resorption • Lytic bone ... lesions (mostly ... - marker of bone
Parosteal Lipoma - MSK Radiology Imaging Findings: • Frontal radiograph displays a radiolucent soft-tissue mass with internal
arise from the bone ... periosteal new bone ... tracer uptake on bone ... scan with new bone ... or neuropathic symptoms
Osgood-Schlatter Disease - MSK Radiology Imaging Findings: • Infrapatellar fat-pad edema with loss of the patellar tendon
Disease - MSK Radiology ... fragmentation and mild bone ... DOES NOT OSD in all ... tear (similar symptoms ... marrow edema and bony
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
= Hypocellular bone ... : - Genetic lesions ... Hypoplastic MDS: • ↓ bone ... • Suggested by bone ... hypoplasia/fatty bone
Cold Urticaria Prevalence - 0.05% in the population Disease onset - Mostly 2nd to 4th decades of life Causes
life Causes and clinical ... and duration of symptoms ... resolve within one ... patients Skin lesions ... doi: 10.1111/all
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