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classification vasculitis agglutinin anemia cold cryofibrinogenemia erythematosus gap hemolytic lupus management myopathy myositis protein proteingap sjogrens sle systemic types vasculitides
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
Syndrome: • Clinical ... diseases: - 10% ... - type II cryoglobulinemia ... #diagnosis #types ... classification #rheumatology
Cryofibrinogenemia Summary Cryofibrinogenemia Epidemiology: • 40-70 years with a modest female predominance Cryofibrinogenemia: • The precipitation of a
Cold insoluble globulin ... Divided Into Two Types ... • Negative causes ... #rheumatology # ... hematology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Hypocomplementemia • Can cause ... salivary ducts Clinical ... Vasculitis: • 7%, Cryoglobulinemia ... Arthralgia and Arthritis ... #Rheumatology #
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
3 Types of Cold ... Cryoglobulins (Vasculitic ... Cold Agglutinin Syndrome ... pts) Differential ... hemolytic #anemia #hematology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
tract, and often causes ... purpura: strong sign ... C-ANCA) pattern: antibodies ... Serologies for Cryoglobulins ... #diagnosis #rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
permanent alopecia Differential ... rheumatologic diseases ... • Type-I Interferonopathies ... Frank nephritis (hypertension ... #Rheumatology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
changes (POEMS syndrome ... (RA, Temporal arteritis ... gastric tumors • Hematology ... Comment on type ... #diagnosis #hematology
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
- Differential ... ) • Shawl sign ... • Nonerosive arthritis ... statins - probably caused ... Myositis #Myopathy #rheumatology
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