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differential dermatology systemic alopecia generalized hairloss management pruritus rheumatology alkaline alp amyloid amyloidosis common cvid diffuse hepatology hyophosphatasia hypogammaglobulinemia immunodeficiency
Pruritus - Generalized Differential Diagnosis Algorithm - Systemic and Primary Causes == Primary Skin Lesions == Macules /
Algorithm - Systemic ... and Primary Causes ... renal failure/uremia ... Pruritus #primary #secondary ... #Algorithm #causes
Nail Disorders secondary to Systemic Diseases Nail Fold Abnormality • SLE • Scleroderma • Dermatomyositis Koilonychia - Spoon-shaped
Nail Disorders secondary ... Iron deficiency anemia ... discoloration) • Liver ... #Diagnosis #Algorithm ... #causes
Hair Loss (Alopecia) - General (Diffuse and Focal) Differential Diagnosis Algorithm DIFFUSE Scarring - Irreversible-biopsy required • Lupus
) Differential Diagnosis ... Algorithm DIFFUSE ... decalvans - Secondary ... to Skin Disease ... #Algorithm #causes
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
- Differential Diagnosis ... purple, hemorrhagic skin ... - Hemolytic anemia ... deficiency • Liver ... #hematology #rheumatology
Pruritus - No Primary Skin Lesion - Differential Diagnosis Algorithm Blood Glucose: • Diabetes Mellitus Liver Function Tests/Enzymes:
Pruritus - No Primary Skin ... Algorithm Blood ... renal failure/uremia ... #Pruritus #secondary ... #Algorithm #causes
Focal / Localized Hair Loss (Alopecia) - Differential Diagnosis Algorithm Scarring - Irreversible-biopsy required - Infectious
Focal / Localized ... - Differential Diagnosis ... Algorithm Scarring ... to Skin Disease ... #Algorithm #causes
Causes of Petechial Rash - Differential Diagnosis Algorithm Pinpoint areas (less than 2 mm) of hemorrhage, which
Causes of Petechial ... Algorithm Pinpoint ... in primary or secondary ... cryoglobulins • Skin ... #Algorithm #Causes
Low Alkaline Phosphatase - Hypophosphatasia Is Low Alkaline Phosphatase Of Clinical Importance? ALP enzyme- Discovered in 1923 Low
synthesized in: liver ... Most cases diagnosed ... pain • loss of secondary ... • Pernicious anemia ... Phosphatase: • Other causes
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
infection risk secondary ... to 8 years Clinical ... disease • Liver ... autoimmune hemolytic anemia ... DDX - Other causes
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
lacrimal glands: • Focal ... other diseases • Secondary ... Hypocomplementemia • Can cause ... salivary ducts Clinical ... vasculitis: 10%-16% Liver
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